In vitro comparison of the acetylcholinesterase inhibition caused by V- and A-series nerve agents’ surrogates

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F23%3A50020597" target="_blank" >RIV/62690094:18470/23:50020597 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0009279723003459?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0009279723003459?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cbi.2023.110678" target="_blank" >10.1016/j.cbi.2023.110678</a>

Jazyk výsledku

angličtina

Název v původním jazyce

In vitro comparison of the acetylcholinesterase inhibition caused by V- and A-series nerve agents’ surrogates

Popis výsledku v původním jazyce

Nerve agents (NA) pose as a great risk in the modern world. NA from the V-series, such as VX, are currently recognized as the most toxic among those compounds. However, the emergence of new classes of toxicants recently included in the Chemical Weapons Convention (CWC), such as the A-series NA, a class of organophosphorus compounds related to phosphoramidates, pose a new source of concern due to the lack of information. In order advance in the investigation on the toxicity of such toxic chemicals, we performed in vitro studies to compare representatives of the V- and A-series using affordable surrogates. Results suggest a similar inhibition potency between both agents. © 2023 Elsevier B.V.

Název v anglickém jazyce

In vitro comparison of the acetylcholinesterase inhibition caused by V- and A-series nerve agents’ surrogates

Popis výsledku anglicky

Nerve agents (NA) pose as a great risk in the modern world. NA from the V-series, such as VX, are currently recognized as the most toxic among those compounds. However, the emergence of new classes of toxicants recently included in the Chemical Weapons Convention (CWC), such as the A-series NA, a class of organophosphorus compounds related to phosphoramidates, pose a new source of concern due to the lack of information. In order advance in the investigation on the toxicity of such toxic chemicals, we performed in vitro studies to compare representatives of the V- and A-series using affordable surrogates. Results suggest a similar inhibition potency between both agents. © 2023 Elsevier B.V.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30108 - Toxicology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemico-biological interactions

ISSN

0009-2797

e-ISSN

1872-7786

Svazek periodika

383

Číslo periodika v rámci svazku

September

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

4

Strana od-do

"Article number: 110678"

Kód UT WoS článku

001106780500001

EID výsledku v databázi Scopus

2-s2.0-85167970991