Formulation study of PLGA in situ films for topical delivery of salicylates

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F24%3A50021501" target="_blank" >RIV/62690094:18470/24:50021501 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/24:10484398

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0939641124001085" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0939641124001085</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejpb.2024.114282" target="_blank" >10.1016/j.ejpb.2024.114282</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Formulation study of PLGA in situ films for topical delivery of salicylates

Popis výsledku v původním jazyce

A film -forming system (FFS) represents a convenient topical dosage form for drug delivery. In this study, a noncommercial poly(lactic-co-glycolic acid) (PLGA) was chosen to formulate an FFS containing salicylic acid (SA) and methyl salicylate (MS). This unique combination is advantageous from a therapeutic point of view, as it enabled modified salicylate release. It is beneficial from a technological perspective too, because it improved thermal, rheological, and adhesive properties of the in situ film. DSC revealed complete dissolution of SA and good miscibility of MS with the polymer. MS also ensures optimal viscoelastic and adhesive properties of the film, leading to prolonged and sustained drug release. The hydrolysis of MS to active SA was very slow at skin pH 5.5, but it apparently occurred at physiological pH 7.4. The film structure is homogeneous without cracks, unlike some commercial preparations. The dissolution study of salicylates revealed different courses in their release and the influence of MS concentration in the film. The formulated PLGA-based FFS containing 5 % SA and 10 % MS is promising for sustained and prolonged local delivery of salicylates, used mainly for keratolytic and antiinflammatory actions and pain relief.

Název v anglickém jazyce

Formulation study of PLGA in situ films for topical delivery of salicylates

Popis výsledku anglicky

A film -forming system (FFS) represents a convenient topical dosage form for drug delivery. In this study, a noncommercial poly(lactic-co-glycolic acid) (PLGA) was chosen to formulate an FFS containing salicylic acid (SA) and methyl salicylate (MS). This unique combination is advantageous from a therapeutic point of view, as it enabled modified salicylate release. It is beneficial from a technological perspective too, because it improved thermal, rheological, and adhesive properties of the in situ film. DSC revealed complete dissolution of SA and good miscibility of MS with the polymer. MS also ensures optimal viscoelastic and adhesive properties of the film, leading to prolonged and sustained drug release. The hydrolysis of MS to active SA was very slow at skin pH 5.5, but it apparently occurred at physiological pH 7.4. The film structure is homogeneous without cracks, unlike some commercial preparations. The dissolution study of salicylates revealed different courses in their release and the influence of MS concentration in the film. The formulated PLGA-based FFS containing 5 % SA and 10 % MS is promising for sustained and prolonged local delivery of salicylates, used mainly for keratolytic and antiinflammatory actions and pain relief.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

ISSN

0939-6411

e-ISSN

1873-3441

Svazek periodika

199

Číslo periodika v rámci svazku

June

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

"Article Number: 114282"

Kód UT WoS článku

001230330300001

EID výsledku v databázi Scopus

2-s2.0-85190355032