c-Jun N-terminal kinase signaling in aging
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F24%3A50021693" target="_blank" >RIV/62690094:18470/24:50021693 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62156489:43210/24:43925701
Výsledek na webu
<a href="https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2024.1453710/full" target="_blank" >https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2024.1453710/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fnagi.2024.1453710" target="_blank" >10.3389/fnagi.2024.1453710</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
c-Jun N-terminal kinase signaling in aging
Popis výsledku v původním jazyce
Aging encompasses a wide array of detrimental effects that compromise physiological functions, elevate the risk of chronic diseases, and impair cognitive abilities. However, the precise underlying mechanisms, particularly the involvement of specific molecular regulatory proteins in the aging process, remain insufficiently understood. Emerging evidence indicates that c-Jun N-terminal kinase (JNK) serves as a potential regulator within the intricate molecular clock governing aging-related processes. JNK demonstrates the ability to diminish telomerase reverse transcriptase activity, elevate beta-galactosidase activity, and induce telomere shortening, thereby contributing to immune system aging. Moreover, the circadian rhythm protein is implicated in JNK-mediated aging. Through this comprehensive review, we meticulously elucidate the intricate regulatory mechanisms orchestrated by JNK signaling in aging processes, offering unprecedented molecular insights with significant implications and highlighting potential therapeutic targets. We also explore the translational impact of targeting JNK signaling for interventions aimed at extending healthspan and promoting longevity.
Název v anglickém jazyce
c-Jun N-terminal kinase signaling in aging
Popis výsledku anglicky
Aging encompasses a wide array of detrimental effects that compromise physiological functions, elevate the risk of chronic diseases, and impair cognitive abilities. However, the precise underlying mechanisms, particularly the involvement of specific molecular regulatory proteins in the aging process, remain insufficiently understood. Emerging evidence indicates that c-Jun N-terminal kinase (JNK) serves as a potential regulator within the intricate molecular clock governing aging-related processes. JNK demonstrates the ability to diminish telomerase reverse transcriptase activity, elevate beta-galactosidase activity, and induce telomere shortening, thereby contributing to immune system aging. Moreover, the circadian rhythm protein is implicated in JNK-mediated aging. Through this comprehensive review, we meticulously elucidate the intricate regulatory mechanisms orchestrated by JNK signaling in aging processes, offering unprecedented molecular insights with significant implications and highlighting potential therapeutic targets. We also explore the translational impact of targeting JNK signaling for interventions aimed at extending healthspan and promoting longevity.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30104 - Pharmacology and pharmacy
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2024
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Frontiers in aging neuroscience
ISSN
1663-4365
e-ISSN
1663-4365
Svazek periodika
16
Číslo periodika v rámci svazku
August
Stát vydavatele periodika
CH - Švýcarská konfederace
Počet stran výsledku
30
Strana od-do
"Article Number: 1453710"
Kód UT WoS článku
001309861100001
EID výsledku v databázi Scopus
2-s2.0-85203833298