Molecular Modeling Insights on the Pharmaceuticals and Hypotheses of Alzheimer's Disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F25%3A50021689" target="_blank" >RIV/62690094:18470/25:50021689 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.eurekaselect.com/article/142820" target="_blank" >https://www.eurekaselect.com/article/142820</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/0109298673318143240823064403" target="_blank" >10.2174/0109298673318143240823064403</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Molecular Modeling Insights on the Pharmaceuticals and Hypotheses of Alzheimer's Disease

Popis výsledku v původním jazyce

Alzheimer&apos;s disease (AD) stands as the predominant contributor to dementia cases. The ongoing developments in our understanding of its pathogenesis have sparked the interest of researchers, driving them to explore innovative treatment approaches. Existing therapies incorporating cholinesterase inhibitors and/or NMDA antagonists have shown limited improvement in alleviating symptoms. This, in turn, highlights the urgency for the pursuit of more effective therapeutic options. Given the annual rise in the number of individuals affected by dementia, it is imperative to allocate resources and efforts towards the exploration of novel therapeutic options. This review aims to provide a comprehensive overview of the AD-related hypotheses, along with the computational approaches employed in research within each hypothesis. In this comprehensive review, the authors shed light on using various computational tools, including diverse case studies, in the pursuit of finding efficacious treatments for AD. The development of more sophisticated diagnostic techniques is crucial, enabling early detection and intervention in the battle against this challenging condition. The potential treatments investigated in this analysis are poised to assume ever more significant functions in both preventing and treating AD, ultimately enhancing the management of the condition and the overall well-being of individuals affected by AD.

Název v anglickém jazyce

Molecular Modeling Insights on the Pharmaceuticals and Hypotheses of Alzheimer's Disease

Popis výsledku anglicky

Alzheimer&apos;s disease (AD) stands as the predominant contributor to dementia cases. The ongoing developments in our understanding of its pathogenesis have sparked the interest of researchers, driving them to explore innovative treatment approaches. Existing therapies incorporating cholinesterase inhibitors and/or NMDA antagonists have shown limited improvement in alleviating symptoms. This, in turn, highlights the urgency for the pursuit of more effective therapeutic options. Given the annual rise in the number of individuals affected by dementia, it is imperative to allocate resources and efforts towards the exploration of novel therapeutic options. This review aims to provide a comprehensive overview of the AD-related hypotheses, along with the computational approaches employed in research within each hypothesis. In this comprehensive review, the authors shed light on using various computational tools, including diverse case studies, in the pursuit of finding efficacious treatments for AD. The development of more sophisticated diagnostic techniques is crucial, enabling early detection and intervention in the battle against this challenging condition. The potential treatments investigated in this analysis are poised to assume ever more significant functions in both preventing and treating AD, ultimately enhancing the management of the condition and the overall well-being of individuals affected by AD.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current medicinal chemistry

ISSN

0929-8673

e-ISSN

1875-533X

Svazek periodika

32

Číslo periodika v rámci svazku

25

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

29

Strana od-do

5110-5138

Kód UT WoS článku

001308405600001

EID výsledku v databázi Scopus

2-s2.0-85215111074