Combining Selective Laser Sintering and Fused Deposition Modeling of Pharmaceutical Polymers: A Novel Approach to Prepare Intestine-Targeted Tablets

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F25%3A50022467" target="_blank" >RIV/62690094:18470/25:50022467 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/25:10505084 RIV/00216275:25310/25:39923091

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/mame.202400460" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/mame.202400460</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mame.202400460" target="_blank" >10.1002/mame.202400460</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Combining Selective Laser Sintering and Fused Deposition Modeling of Pharmaceutical Polymers: A Novel Approach to Prepare Intestine-Targeted Tablets

Popis výsledku v původním jazyce

This study introduces a novel approach to prepare an intestine-targeting transport system with a controlled drug release profile, combining two 3D printing techniques: selective laser sintering (SLS) and fused deposition modeling (FDM). Material evaluations indicate that a mixture of Kollidon (R) VA64 with 20% of Kollicoat (R) IR and 0.2% of Aeroperl (R) has the best flow behavior and exhibits optimal printability at a laser speed of 90 mm s-1. The formulation is subsequently drug-loaded and the printed cores are coated using the FDM technique. The core serves as a drug carrier and the FDM coating shell, consisting of 95% HPMC and 5% pectin, provides modified drug release and enhanced mechanical resistance of the tablet. The coating exhibits acid-resistant properties, with no drug release in the pH of 1.2 during the first 120 min of dissolution testing. In the pH of 6.8, the release profile shows zero-order kinetics with a constant release rate of 0.249% min-1 (in the time interval from 255 to 480 min). At the time point of 720 min, 92% of the drug is released. Dissolution testing thus demonstrates delayed and prolonged drug release. Combining both 3D printing methods shows great potential for personalized treatment of intestinal inflammatory diseases.

Název v anglickém jazyce

Combining Selective Laser Sintering and Fused Deposition Modeling of Pharmaceutical Polymers: A Novel Approach to Prepare Intestine-Targeted Tablets

Popis výsledku anglicky

This study introduces a novel approach to prepare an intestine-targeting transport system with a controlled drug release profile, combining two 3D printing techniques: selective laser sintering (SLS) and fused deposition modeling (FDM). Material evaluations indicate that a mixture of Kollidon (R) VA64 with 20% of Kollicoat (R) IR and 0.2% of Aeroperl (R) has the best flow behavior and exhibits optimal printability at a laser speed of 90 mm s-1. The formulation is subsequently drug-loaded and the printed cores are coated using the FDM technique. The core serves as a drug carrier and the FDM coating shell, consisting of 95% HPMC and 5% pectin, provides modified drug release and enhanced mechanical resistance of the tablet. The coating exhibits acid-resistant properties, with no drug release in the pH of 1.2 during the first 120 min of dissolution testing. In the pH of 6.8, the release profile shows zero-order kinetics with a constant release rate of 0.249% min-1 (in the time interval from 255 to 480 min). At the time point of 720 min, 92% of the drug is released. Dissolution testing thus demonstrates delayed and prolonged drug release. Combining both 3D printing methods shows great potential for personalized treatment of intestinal inflammatory diseases.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MACROMOLECULAR MATERIALS AND ENGINEERING

ISSN

1438-7492

e-ISSN

1439-2054

Svazek periodika

310

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

13

Strana od-do

"Article number: 2400460"

Kód UT WoS článku

001426031600001

EID výsledku v databázi Scopus

2-s2.0-85219699128