Special nanofiber scaffold designed for cellular products in the treatment of chronic wounds

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F64577732%3A_____%2F20%3AN0000001" target="_blank" >RIV/64577732:_____/20:N0000001 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21460/21:00354514

Výsledek na webu

<a href="https://www.confer.cz/nanocon/2020/3753-special-nanofiber-scaffold-designed-for-cellular-products-in-the-treatment-of-chronic-wounds" target="_blank" >https://www.confer.cz/nanocon/2020/3753-special-nanofiber-scaffold-designed-for-cellular-products-in-the-treatment-of-chronic-wounds</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.37904/nanocon.2020.3753" target="_blank" >10.37904/nanocon.2020.3753</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Special nanofiber scaffold designed for cellular products in the treatment of chronic wounds

Popis výsledku v původním jazyce

In this work we have prepared and characterized several types of nanofibers to create unique nanofiber substrates as a medical device for long-term non-healing wound treating using cellular products. Our nanofibers are based on biodegradable polymers such as polycaprolactone (PCL), poly(lactide-co-caprolactone) (PLCL), poly(vinyl)alcohol (PVA), polyethyleneimine (PEI) and hyaluronic acid. Prepared nanofiber carriers were specifically adjusted for the autologous MSCs (mesenchymal stromal cells) applications on the chronic wound. In addition, the nanofiber sheets were constructed as a biodegradable material to guarantee proper timing of its resorption in a chronic wound during the healing process. Furthermore, the effect of growth factors on MSC proliferation was tested. The release of bFGF from adsorbed lipid particles was tested. The results show increased proliferation of MSCs. Despite fast increasing advanced technologies in healthcare, chronic wound treating tends to be still very difficult and challenging. Our developed nanofiber-based dressings are very promising for poorly healing wound therapy using MSCs. The main goal is to make chronic wound healing more effective and decrease a time of healing process. This work was performed as part of the project FV20422 "Development of nanofibrous scaffolds ensuring application of cellular products, including physical stimulation effect, with the intended purpose of the treatment of chronic wounds".

Název v anglickém jazyce

Special nanofiber scaffold designed for cellular products in the treatment of chronic wounds

Popis výsledku anglicky

In this work we have prepared and characterized several types of nanofibers to create unique nanofiber substrates as a medical device for long-term non-healing wound treating using cellular products. Our nanofibers are based on biodegradable polymers such as polycaprolactone (PCL), poly(lactide-co-caprolactone) (PLCL), poly(vinyl)alcohol (PVA), polyethyleneimine (PEI) and hyaluronic acid. Prepared nanofiber carriers were specifically adjusted for the autologous MSCs (mesenchymal stromal cells) applications on the chronic wound. In addition, the nanofiber sheets were constructed as a biodegradable material to guarantee proper timing of its resorption in a chronic wound during the healing process. Furthermore, the effect of growth factors on MSC proliferation was tested. The release of bFGF from adsorbed lipid particles was tested. The results show increased proliferation of MSCs. Despite fast increasing advanced technologies in healthcare, chronic wound treating tends to be still very difficult and challenging. Our developed nanofiber-based dressings are very promising for poorly healing wound therapy using MSCs. The main goal is to make chronic wound healing more effective and decrease a time of healing process. This work was performed as part of the project FV20422 "Development of nanofibrous scaffolds ensuring application of cellular products, including physical stimulation effect, with the intended purpose of the treatment of chronic wounds".

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

<a href="/cs/project/FV20422" target="_blank" >FV20422: Vývoj nanovlákenných scaffoldů zajišťujících aplikaci celulárních produktů, včetně fyzikální stimulace účinku, s účelem určení pro léčbu chronických ran</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings 12th International Conference on Nanomaterials - Research & Application

ISBN

978-80-87294-98-7

ISSN

2694-930X

e-ISSN

—

Počet stran výsledku

7

Strana od-do

—

Název nakladatele

—

Místo vydání

—

Místo konání akce

Brno

Datum konání akce

1. 1. 2020

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

—