Painful or painless lower limb dysesthesias are highly predictive of peripheral neuropathy: Comparison of different diagnostic modalities

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F09%3A%230000803" target="_blank" >RIV/65269705:_____/09:#0000803 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Painful or painless lower limb dysesthesias are highly predictive of peripheral neuropathy: Comparison of different diagnostic modalities

Popis výsledku v původním jazyce

42 patients were recruited prospectively and underwent a clinical examination,nerve conduction studies, quantitative sensory testing(QST)and skin biopsy at the dorsum of the foot.All patients had a correlate for their dysesthesias in at least one diagnostic modality.Most patients(>90%)had signs of small fiber loss or dysfunction.In about half of all patients large fibers were also affected.Nerve conduction studies were abnormal in 23/42 patients(54.8%).Cold or warm detection thresholds in QST were abnormal in 15/42(35.7%)patients.Decreased intraepidermal nerve fiber density(IENFD)was found in 37 patients(88.1%)including some patients with normal QST findings.Nearly all patients with pathological QST had a reduced IENFD,indicating a high positive predictive value(93%)of QST in screening for reduced IENFD as correlate for neuropathy.Therefore in all patients with lower limb dysesthesias of unknown origin,the non-invasive methods of NCS and QST should be used and potentially complemented

Název v anglickém jazyce

Painful or painless lower limb dysesthesias are highly predictive of peripheral neuropathy: Comparison of different diagnostic modalities

Popis výsledku anglicky

42 patients were recruited prospectively and underwent a clinical examination,nerve conduction studies, quantitative sensory testing(QST)and skin biopsy at the dorsum of the foot.All patients had a correlate for their dysesthesias in at least one diagnostic modality.Most patients(>90%)had signs of small fiber loss or dysfunction.In about half of all patients large fibers were also affected.Nerve conduction studies were abnormal in 23/42 patients(54.8%).Cold or warm detection thresholds in QST were abnormal in 15/42(35.7%)patients.Decreased intraepidermal nerve fiber density(IENFD)was found in 37 patients(88.1%)including some patients with normal QST findings.Nearly all patients with pathological QST had a reduced IENFD,indicating a high positive predictive value(93%)of QST in screening for reduced IENFD as correlate for neuropathy.Therefore in all patients with lower limb dysesthesias of unknown origin,the non-invasive methods of NCS and QST should be used and potentially complemented

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Pain

ISSN

1090-3801

e-ISSN

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Svazek periodika

13

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000268384500006

EID výsledku v databázi Scopus

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