Transplantation of Allogeneic Mesenchymal Stem Cells into Physeal Defects in the Prevention of Bone Bridge Formation in Pigs
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F10%3A%230001196" target="_blank" >RIV/65269705:_____/10:#0001196 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Transplantation of Allogeneic Mesenchymal Stem Cells into Physeal Defects in the Prevention of Bone Bridge Formation in Pigs
Popis výsledku v původním jazyce
Following a trauma, the capacity of the growth plate to regenerate tends to decrease. Evaluating the capacity of mesenchymal stem cells (MSCs) to heal defects in the injured physis is one of the current issues of contemporary research. Our study draws ona successful experiment with similar objectives which was previously carried out on the model of a New Zealand white rabbit. Long-term research included a group of 10 miniature pigs: allogeneic mesenchymal stem cells were transplanted into an iatrogenically-induced defect in the lateral section of the distal physis of the left femur. The right femur with the same defect in the distal physis, but without transplanted stem cells, served as a control. To transfer MSCs, a recently developed porous scaffoldwas used, based on collagen and chitosan, constituting a compact tube into which MSCs were implanted. The pigs were euthanized 4 months after the transplantation.
Název v anglickém jazyce
Transplantation of Allogeneic Mesenchymal Stem Cells into Physeal Defects in the Prevention of Bone Bridge Formation in Pigs
Popis výsledku anglicky
Following a trauma, the capacity of the growth plate to regenerate tends to decrease. Evaluating the capacity of mesenchymal stem cells (MSCs) to heal defects in the injured physis is one of the current issues of contemporary research. Our study draws ona successful experiment with similar objectives which was previously carried out on the model of a New Zealand white rabbit. Long-term research included a group of 10 miniature pigs: allogeneic mesenchymal stem cells were transplanted into an iatrogenically-induced defect in the lateral section of the distal physis of the left femur. The right femur with the same defect in the distal physis, but without transplanted stem cells, served as a control. To transfer MSCs, a recently developed porous scaffoldwas used, based on collagen and chitosan, constituting a compact tube into which MSCs were implanted. The pigs were euthanized 4 months after the transplantation.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
FI - Traumatologie a ortopedie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/NS9896" target="_blank" >NS9896: Využití nanotechnologií a biomateriálů v kombinaci s mezenchymovými kmenovými buňkami v léčbě poškozené fyzární růstové ploténky - experimentální studie.</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2010
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů