Clinical and laboratory features of leukemias at the time of diagnosis: An analysis of 1,004 consecutive patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F11%3A%230001355" target="_blank" >RIV/65269705:_____/11:#0001355 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/11:00053037 RIV/00023736:_____/11:00009282

Výsledek na webu

<a href="http://dx.doi.org/10.1002/ajh.22100" target="_blank" >http://dx.doi.org/10.1002/ajh.22100</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ajh.22100" target="_blank" >10.1002/ajh.22100</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Clinical and laboratory features of leukemias at the time of diagnosis: An analysis of 1,004 consecutive patients

Popis výsledku v původním jazyce

To determine the major presenting features of the most frequent leukemias and to describe the period from the first symptoms to the final diagnosis, we analyzed the records of 1,004 consecutive patients with acute (AL) and chronic (CL) leukemias diagnosed between 2004 and 2009. In 24% of AL and 63% of CL, the diagnosis was made incidentally. In contrast to the frequency of the symptoms, their spectrum did not differ from historical studies, and fatigue and weakness were the most frequent symptoms observed [with the exception of acute promyelocytic leukemia (APL) where bleeding predominated]. More profound cytopenia was found in AL compared to CL. The median time from the first symptoms to final diagnosis was 3 weeks in AL and 4 weeks in CL. APL had theshortest time to a definitive diagnosis (2weeks); however, a very short duration of symptoms was also observed in CML (3 weeks). This study is the largest series reported to date on symptoms in leukemia patients at the time of diagnosis,

Název v anglickém jazyce

Clinical and laboratory features of leukemias at the time of diagnosis: An analysis of 1,004 consecutive patients

Popis výsledku anglicky

To determine the major presenting features of the most frequent leukemias and to describe the period from the first symptoms to the final diagnosis, we analyzed the records of 1,004 consecutive patients with acute (AL) and chronic (CL) leukemias diagnosed between 2004 and 2009. In 24% of AL and 63% of CL, the diagnosis was made incidentally. In contrast to the frequency of the symptoms, their spectrum did not differ from historical studies, and fatigue and weakness were the most frequent symptoms observed [with the exception of acute promyelocytic leukemia (APL) where bleeding predominated]. More profound cytopenia was found in AL compared to CL. The median time from the first symptoms to final diagnosis was 3 weeks in AL and 4 weeks in CL. APL had theshortest time to a definitive diagnosis (2weeks); however, a very short duration of symptoms was also observed in CML (3 weeks). This study is the largest series reported to date on symptoms in leukemia patients at the time of diagnosis,

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Hematology

ISSN

0361-8609

e-ISSN

—

Svazek periodika

86

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

800-803

Kód UT WoS článku

000295003800019

EID výsledku v databázi Scopus

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