Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F11%3A%230001542" target="_blank" >RIV/65269705:_____/11:#0001542 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/11:00054011

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jns.2011.01.020" target="_blank" >http://dx.doi.org/10.1016/j.jns.2011.01.020</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jns.2011.01.020" target="_blank" >10.1016/j.jns.2011.01.020</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate

Popis výsledku v původním jazyce

A total of 195 patients with multiple sclerosis (MS) and 126 controls were investigated for angiotensinogen/(-6)A/G, M235T/and angiotensin converting enzyme I/D gene polymorphisms to test their association with MS susceptibility and/or disease progression using Global Multiple Sclerosis Severity Score (MSSS). We demonstrated a significant association of M235T polymorphism with MSSS. The MM homozygotes had the lowest (3.8), heterozygotes MT higher (5.2) and homozygotes TT the highest (5.4) mean MSSS values (P = 0.02). For polymorphisms (-6)A/G of ATG, only a trend was observed (P = 0.06), where the homozygotes GG carried lower MSSS values than heterozygotes and homozygotes AA. No significant association with susceptibility was observed. For ACE I/D polymorphism, neither significant differences in the genotype-phenotype study nor in the case-control study were observed.

Název v anglickém jazyce

Two frequent polymorphisms of angiotensinogen and their association with multiple sclerosis progression rate

Popis výsledku anglicky

A total of 195 patients with multiple sclerosis (MS) and 126 controls were investigated for angiotensinogen/(-6)A/G, M235T/and angiotensin converting enzyme I/D gene polymorphisms to test their association with MS susceptibility and/or disease progression using Global Multiple Sclerosis Severity Score (MSSS). We demonstrated a significant association of M235T polymorphism with MSSS. The MM homozygotes had the lowest (3.8), heterozygotes MT higher (5.2) and homozygotes TT the highest (5.4) mean MSSS values (P = 0.02). For polymorphisms (-6)A/G of ATG, only a trend was observed (P = 0.06), where the homozygotes GG carried lower MSSS values than heterozygotes and homozygotes AA. No significant association with susceptibility was observed. For ACE I/D polymorphism, neither significant differences in the genotype-phenotype study nor in the case-control study were observed.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the Neurological Sciences

ISSN

0022-510X

e-ISSN

—

Svazek periodika

303

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

4

Strana od-do

31-34

Kód UT WoS článku

000289339900004

EID výsledku v databázi Scopus

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