Multifunctional immune-modulatory protein HLA-E identified in classical Hodkin lymphoma: Possible implications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F12%3A%230001845" target="_blank" >RIV/65269705:_____/12:#0001845 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.prp.2011.11.004" target="_blank" >http://dx.doi.org/10.1016/j.prp.2011.11.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.prp.2011.11.004" target="_blank" >10.1016/j.prp.2011.11.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Multifunctional immune-modulatory protein HLA-E identified in classical Hodkin lymphoma: Possible implications

Popis výsledku v původním jazyce

Although the role of the non-classical human leukocyte antigen E (HLA-E) was originally thought to be limited to the development of a maternal tolerance to a semiallogeneic fetal graft, it is now known that HLA-E exerts multiple immunoregulatory functions. The significance of the presence of HLA-E in neoplastic cells and/or background microenvironment cells in classical Hodgkin lymphoma (cHL) is not well characterized. In our study, we evaluated the presence of HLA-E in both neoplastic and background cells in 40 cases of cHL. We found HLA-E in both neoplastic and background cells. There was a positive statistical correlation between the expression of HLA-E in neoplastic cells and the clinical stage of the disease, which indicates an immune-tolerogenicproperty of this multiple-purpose molecule. The presence of HLA-E in background cells seems to be prognostically neutral but its significance still needs to be determined. The mechanisms regulating the immunopathology of cHL neoplastic ce

Název v anglickém jazyce

Multifunctional immune-modulatory protein HLA-E identified in classical Hodkin lymphoma: Possible implications

Popis výsledku anglicky

Although the role of the non-classical human leukocyte antigen E (HLA-E) was originally thought to be limited to the development of a maternal tolerance to a semiallogeneic fetal graft, it is now known that HLA-E exerts multiple immunoregulatory functions. The significance of the presence of HLA-E in neoplastic cells and/or background microenvironment cells in classical Hodgkin lymphoma (cHL) is not well characterized. In our study, we evaluated the presence of HLA-E in both neoplastic and background cells in 40 cases of cHL. We found HLA-E in both neoplastic and background cells. There was a positive statistical correlation between the expression of HLA-E in neoplastic cells and the clinical stage of the disease, which indicates an immune-tolerogenicproperty of this multiple-purpose molecule. The presence of HLA-E in background cells seems to be prognostically neutral but its significance still needs to be determined. The mechanisms regulating the immunopathology of cHL neoplastic ce

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/NS9871" target="_blank" >NS9871: Využití dendritických buněk naložených univerzálními nádorovými antigeny pro přípravu protinádorových vakcín</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pathology, research and practice

ISSN

0344-0338

e-ISSN

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Svazek periodika

208

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

5

Strana od-do

45-49

Kód UT WoS článku

000300602900007

EID výsledku v databázi Scopus

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