MicroRNA signature associated with poor outcome of glioblastoma patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F14%3A00062729" target="_blank" >RIV/65269705:_____/14:00062729 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/14:00080178

Výsledek na webu

<a href="http://neuro-oncology.oxfordjournals.org/content/16/suppl_5/v126.2" target="_blank" >http://neuro-oncology.oxfordjournals.org/content/16/suppl_5/v126.2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/neuonc/nou262.6" target="_blank" >10.1093/neuonc/nou262.6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MicroRNA signature associated with poor outcome of glioblastoma patients

Popis výsledku v původním jazyce

BACKGROUND: It is very important to find new biomarkers which can predict clinical outcomes of glioblastoma (GBM) and help in treatment decissions. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression and play key role in pathogenesis of wide range of cancer. Aim of our study is to identify miRNA signature associated with the more aggressive phenotype of GBMs, which will enable sensitive prediction of clinical outcome in GBM patients. METHODS:We determined the expression profile of 667 miRNAs in tumor tissues of 58 patients with primary GBM with completed concomitant chemoradiotherapy with temozolomide and 12 non-malignant brain tissues obtained from patients with drug-resistant anteromedialtemporal lobe epilepsy. Methylation status of MGMT promoter (methylation-specific HRM), isocitrate dehydrogenase (IDH1) status (immunohistochemistry) and co-deletion of 1p/19q (FISH) was also evaluated. RESULTS: We have confirmed frequen

Název v anglickém jazyce

MicroRNA signature associated with poor outcome of glioblastoma patients

Popis výsledku anglicky

BACKGROUND: It is very important to find new biomarkers which can predict clinical outcomes of glioblastoma (GBM) and help in treatment decissions. MicroRNAs (miRNAs) are small, non-coding RNAs that function as post-transcriptional regulators of gene expression and play key role in pathogenesis of wide range of cancer. Aim of our study is to identify miRNA signature associated with the more aggressive phenotype of GBMs, which will enable sensitive prediction of clinical outcome in GBM patients. METHODS:We determined the expression profile of 667 miRNAs in tumor tissues of 58 patients with primary GBM with completed concomitant chemoradiotherapy with temozolomide and 12 non-malignant brain tissues obtained from patients with drug-resistant anteromedialtemporal lobe epilepsy. Methylation status of MGMT promoter (methylation-specific HRM), isocitrate dehydrogenase (IDH1) status (immunohistochemistry) and co-deletion of 1p/19q (FISH) was also evaluated. RESULTS: We have confirmed frequen

Druh

O - Ostatní výsledky

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů