Superiority of SPECT/CT over planar I-123-mIBG images in neuroblastoma patients with impact on Curie and SIOPEN score values

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F16%3A00065796" target="_blank" >RIV/65269705:_____/16:00065796 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00091987

Výsledek na webu

<a href="https://nuk.schattauer.de/inhalt/archivestandard/issue/2381/manuscript/25718.html" target="_blank" >https://nuk.schattauer.de/inhalt/archivestandard/issue/2381/manuscript/25718.html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3413/Nukmed-0743-15-05" target="_blank" >10.3413/Nukmed-0743-15-05</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Superiority of SPECT/CT over planar I-123-mIBG images in neuroblastoma patients with impact on Curie and SIOPEN score values

Popis výsledku v původním jazyce

Objective: The existing most common semi quantitative systems used for neuroblastoma diagnosis include Curie and SIOPEN scores, which are based on I-123-MIBG planar scans. The purpose of our study was to find out whether a statistically significant difference exists in evaluation based on planar and SPECT/CT scans. We also compared the Curie and SIOPEN methods in terms of their use in regular practice. Patients; method: 45 patients aged 0-10 years; 213 assessments were done in total, and the Curie and SIOPEN scores were determined in each case based on planar and SPECT/CT scans. Student's T-test and the Bland-Altman plot were used for the statistical analysis. Results: Both methods demonstrated a statistically significant difference (p < 0.0001) between planar and SPECT/CT evaluation. In the group of 35 patients with neuroblastoma in clinical stages 3 and 4, in 54% of the patients SPECT/CT detected a lesion that was not visible in the planar scan. In 89% of cases, the lesion was confirmed by another imaging method (CT, MRI). In the group of 10 patients in the clinical stage 1, a difference between planar and SPECT/CT scanning was found only in one patient (10%). In the whole set, 25% patients showed a pathological finding only in soft tissues. Conclusion: We recommend to perform semiquantitative evaluation of neuroblastoma based on SPECT/CT scans, particularly in patients in clinical stages 3 and 4. It is advisable to include soft tissues in the score assessment, as well, given that only soft tissues may be involved in up to 25%

Název v anglickém jazyce

Superiority of SPECT/CT over planar I-123-mIBG images in neuroblastoma patients with impact on Curie and SIOPEN score values

Popis výsledku anglicky

Objective: The existing most common semi quantitative systems used for neuroblastoma diagnosis include Curie and SIOPEN scores, which are based on I-123-MIBG planar scans. The purpose of our study was to find out whether a statistically significant difference exists in evaluation based on planar and SPECT/CT scans. We also compared the Curie and SIOPEN methods in terms of their use in regular practice. Patients; method: 45 patients aged 0-10 years; 213 assessments were done in total, and the Curie and SIOPEN scores were determined in each case based on planar and SPECT/CT scans. Student's T-test and the Bland-Altman plot were used for the statistical analysis. Results: Both methods demonstrated a statistically significant difference (p < 0.0001) between planar and SPECT/CT evaluation. In the group of 35 patients with neuroblastoma in clinical stages 3 and 4, in 54% of the patients SPECT/CT detected a lesion that was not visible in the planar scan. In 89% of cases, the lesion was confirmed by another imaging method (CT, MRI). In the group of 10 patients in the clinical stage 1, a difference between planar and SPECT/CT scanning was found only in one patient (10%). In the whole set, 25% patients showed a pathological finding only in soft tissues. Conclusion: We recommend to perform semiquantitative evaluation of neuroblastoma based on SPECT/CT scans, particularly in patients in clinical stages 3 and 4. It is advisable to include soft tissues in the score assessment, as well, given that only soft tissues may be involved in up to 25%

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nuklearmedizin-Nuclear Medicine

ISSN

0029-5566

e-ISSN

—

Svazek periodika

55

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

151-157

Kód UT WoS článku

000381451900004

EID výsledku v databázi Scopus

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