Can we improve the therapy of Clostridium difficile infection in elderly patients?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F16%3A00065959" target="_blank" >RIV/65269705:_____/16:00065959 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00092333 RIV/00216305:26210/16:PU121953

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00508-016-1056-z" target="_blank" >http://dx.doi.org/10.1007/s00508-016-1056-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00508-016-1056-z" target="_blank" >10.1007/s00508-016-1056-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Can we improve the therapy of Clostridium difficile infection in elderly patients?

Popis výsledku v původním jazyce

Clostridium difficile infection (CDI) is becoming a serious problem predominantly in geriatric patients, who are a significant risk group. The goal of this study was to evaluate the risk factors for mortality in CDI patients and to construct a binary logistic regression model that describes the probability of mortality in geriatric patients suffering from CDI. In this retrospective study, we evaluated a group of 235 patients over 65 years of age with confirmed diagnoses of CDI, hospitalized at the Department of Internal Medicine, Geriatrics and General Practice, Brno, from January 2008 to December 2013. The examined group comprised 148 women (63 %) and 87 men (37 %). For the diagnosis of CDI, confirmation of A and B toxins in the patients' stool or an autopsy confirmation was crucial. The impact of antibiotic therapy on the increased incidence of CDI was clearly confirmed in our study group when examining patients' histories. Other risk factors included cerebrovascular disease, dementia, the presence of pressure ulcers, and immobility. Our new model consisted of a combination of the following parameters: the number of antibiotics used (from patients' history), nutritional status (Mini Nutritional Assessment short-form test), presence of pressure ulcers, and occurrence of fever. Our logistic regression model may predict mortality in geriatric patients suffering from CDI. This could help improve the therapeutic process.

Název v anglickém jazyce

Can we improve the therapy of Clostridium difficile infection in elderly patients?

Popis výsledku anglicky

Clostridium difficile infection (CDI) is becoming a serious problem predominantly in geriatric patients, who are a significant risk group. The goal of this study was to evaluate the risk factors for mortality in CDI patients and to construct a binary logistic regression model that describes the probability of mortality in geriatric patients suffering from CDI. In this retrospective study, we evaluated a group of 235 patients over 65 years of age with confirmed diagnoses of CDI, hospitalized at the Department of Internal Medicine, Geriatrics and General Practice, Brno, from January 2008 to December 2013. The examined group comprised 148 women (63 %) and 87 men (37 %). For the diagnosis of CDI, confirmation of A and B toxins in the patients' stool or an autopsy confirmation was crucial. The impact of antibiotic therapy on the increased incidence of CDI was clearly confirmed in our study group when examining patients' histories. Other risk factors included cerebrovascular disease, dementia, the presence of pressure ulcers, and immobility. Our new model consisted of a combination of the following parameters: the number of antibiotics used (from patients' history), nutritional status (Mini Nutritional Assessment short-form test), presence of pressure ulcers, and occurrence of fever. Our logistic regression model may predict mortality in geriatric patients suffering from CDI. This could help improve the therapeutic process.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/LO1202" target="_blank" >LO1202: NETME CENTRE PLUS</a><br>

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Wiener Klinische Wochenschrift

ISSN

0043-5325

e-ISSN

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Svazek periodika

128

Číslo periodika v rámci svazku

15-16

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

592-598

Kód UT WoS článku

000382676200008

EID výsledku v databázi Scopus

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