Risperidone increases the cortical silent period in drug-naive patients with first-episode schizophrenia: A transcranial magnetic stimulation study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F17%3A00067857" target="_blank" >RIV/65269705:_____/17:00067857 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14740/17:00096842

Výsledek na webu

<a href="http://journals.sagepub.com/doi/abs/10.1177/0269881116662650" target="_blank" >http://journals.sagepub.com/doi/abs/10.1177/0269881116662650</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/0269881116662650" target="_blank" >10.1177/0269881116662650</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Risperidone increases the cortical silent period in drug-naive patients with first-episode schizophrenia: A transcranial magnetic stimulation study

Popis výsledku v původním jazyce

Objectives: Schizophrenia is accompanied by impaired cortical inhibition, as measured by several markers including the cortical silent period (CSP). It is thought that CSP measures gamma-aminobutyric acid receptors B (GABA(B)) mediated inhibitory activity. But the mutual roles of schizophrenia as a disease and the drugs used for the treatment of psychosis on GABA mediated neurotransmission are not clear. Methods: We recruited 13 drug-naive patients with first-episode schizophrenia. We used transcranial magnetic stimulation to assess CSP prior to initiating risperidone monotherapy and again four weeks later. At the same time, we rated the severity of psychopathology using the Positive and Negative Syndrome Scale (PANSS). Results: We obtained data from 12 patients who showed a significant increase in CSP, from 134.2041.81 ms to 162.95 +/- 61.98 ms (p=0.041; Cohen&apos;s d=0.544). After the treatment, the PANSS total score was significantly lower, as were the individual subscores (p&lt;0.05). However, no correlation was found between CSP and PANSS. Conclusion: Our study in patients with first-episode schizophrenia demonstrated an association between risperidone monotherapy and an increase in GABA(B) mediated inhibitory neurotransmission.

Název v anglickém jazyce

Risperidone increases the cortical silent period in drug-naive patients with first-episode schizophrenia: A transcranial magnetic stimulation study

Popis výsledku anglicky

Objectives: Schizophrenia is accompanied by impaired cortical inhibition, as measured by several markers including the cortical silent period (CSP). It is thought that CSP measures gamma-aminobutyric acid receptors B (GABA(B)) mediated inhibitory activity. But the mutual roles of schizophrenia as a disease and the drugs used for the treatment of psychosis on GABA mediated neurotransmission are not clear. Methods: We recruited 13 drug-naive patients with first-episode schizophrenia. We used transcranial magnetic stimulation to assess CSP prior to initiating risperidone monotherapy and again four weeks later. At the same time, we rated the severity of psychopathology using the Positive and Negative Syndrome Scale (PANSS). Results: We obtained data from 12 patients who showed a significant increase in CSP, from 134.2041.81 ms to 162.95 +/- 61.98 ms (p=0.041; Cohen&apos;s d=0.544). After the treatment, the PANSS total score was significantly lower, as were the individual subscores (p&lt;0.05). However, no correlation was found between CSP and PANSS. Conclusion: Our study in patients with first-episode schizophrenia demonstrated an association between risperidone monotherapy and an increase in GABA(B) mediated inhibitory neurotransmission.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30215 - Psychiatry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Psychopharmacology

ISSN

0269-8811

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

500-504

Kód UT WoS článku

000400179400010

EID výsledku v databázi Scopus

2-s2.0-85018722692