Vulvar cancer recurrence - an analysis of prognostic factors in tumour-free pathological margins patients group

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F18%3A00069190" target="_blank" >RIV/65269705:_____/18:00069190 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/18:00104063

Výsledek na webu

<a href="https://journals.viamedica.pl/ginekologia_polska/article/view/58403" target="_blank" >https://journals.viamedica.pl/ginekologia_polska/article/view/58403</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5603/GP.a2018.0073" target="_blank" >10.5603/GP.a2018.0073</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Vulvar cancer recurrence - an analysis of prognostic factors in tumour-free pathological margins patients group

Popis výsledku v původním jazyce

Objectives:To evaluate risk factors associated with the local recurrence of invasive squamous cell vulvar cancer in patient group with tumor-free pathological margins. Material and methods: This is a retrospective analysis of 47 patients who underwent surgical treatment at University Hospital Brno, the Czech Republic between 2007 and 2014. 24 patients were classified as IB stage and three as II stage. A further 20 patients representing stage III showed the metastatic involvement of regional lymph nodes. Seven prognostic factors were analyzed in relation to local tumour recurrence: tumour size, margin distance, depth of invasion, lymphovascular space involvement (LVSI), midline involvement, metastatic lymph nodes and FIGO stage. Results: All prognostic factors were found to be statistically significant with respect to the risk of local recurrence. The highest risk of local recurrence was observed for the depth of invasion &gt; 5 mm (HR, 12.42 [95% CI; 3.44-44.841) and for the presence of LVSI (HR, 10.83 [95% CI; 3.87-30.28]).The study also established a clear difference in the risk of local recurrence between patient groups with resection margin &lt; 8 vs. &gt;= 8 mm (HR, 4.91 [95% CI; 1.73-13.93; p = 0.003]. Conclusions: Tumour-free pathological margin of &gt;= 8 mm is a major prognostic factor of local recurrence which can be influenced by the surgeon. A perfect knowledge of the extent of the disease prior to surgery supports adequately radical surgical trends. The emphasis is given on adequate radicality as well as on the reduction of overtreatment without worsening prognosis by simultaneously preserving the quality of life.

Název v anglickém jazyce

Vulvar cancer recurrence - an analysis of prognostic factors in tumour-free pathological margins patients group

Popis výsledku anglicky

Objectives:To evaluate risk factors associated with the local recurrence of invasive squamous cell vulvar cancer in patient group with tumor-free pathological margins. Material and methods: This is a retrospective analysis of 47 patients who underwent surgical treatment at University Hospital Brno, the Czech Republic between 2007 and 2014. 24 patients were classified as IB stage and three as II stage. A further 20 patients representing stage III showed the metastatic involvement of regional lymph nodes. Seven prognostic factors were analyzed in relation to local tumour recurrence: tumour size, margin distance, depth of invasion, lymphovascular space involvement (LVSI), midline involvement, metastatic lymph nodes and FIGO stage. Results: All prognostic factors were found to be statistically significant with respect to the risk of local recurrence. The highest risk of local recurrence was observed for the depth of invasion &gt; 5 mm (HR, 12.42 [95% CI; 3.44-44.841) and for the presence of LVSI (HR, 10.83 [95% CI; 3.87-30.28]).The study also established a clear difference in the risk of local recurrence between patient groups with resection margin &lt; 8 vs. &gt;= 8 mm (HR, 4.91 [95% CI; 1.73-13.93; p = 0.003]. Conclusions: Tumour-free pathological margin of &gt;= 8 mm is a major prognostic factor of local recurrence which can be influenced by the surgeon. A perfect knowledge of the extent of the disease prior to surgery supports adequately radical surgical trends. The emphasis is given on adequate radicality as well as on the reduction of overtreatment without worsening prognosis by simultaneously preserving the quality of life.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Ginekologia Polska

ISSN

0017-0011

e-ISSN

—

Svazek periodika

89

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

8

Strana od-do

424-431

Kód UT WoS článku

000444810900004

EID výsledku v databázi Scopus

2-s2.0-85052687294