Residual neuromuscular block in paediatric anaesthesia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00070512" target="_blank" >RIV/65269705:_____/19:00070512 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/19:00109048

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0007091218307670?via%3Dihub#" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0007091218307670?via%3Dihub#</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bja.2018.10.001" target="_blank" >10.1016/j.bja.2018.10.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Residual neuromuscular block in paediatric anaesthesia

Popis výsledku v původním jazyce

Background: Residual neuromuscular blockade (RNB) in postoperative period is frequent (26-88%) and it is associated with negative impact on perioperative morbidity. The safety cut-off measured by accelerometry is currently defined as Train-of-four ratio (TOFr) &gt;= 0.9. The primary outcome of the study was detect the incidence of RNB measured just prior extubation in the operating room (OR) (according to pragmatic trial design) and the secondary outcome was the incidence of the RNB in postanaethesia care unit (PACU). Methods: After Ethics Committee (10/2016) approval, paediatric patients (1.1.2017-31.12.2017) undergoing surgery in general anaesthesia with muscle relaxation were included in the study. The level of blockade was measured just prior to extubation in OR (patient eligible for extubation according to the anesthesiologist) and after arrival at PACU with acceleromtery - TOF-Watch(R)SX (Organon, Inc, West Orange, NJ). The mode for measurement was Train-of-four (TOF) and Train-of-four ratio (TOFr), in case of deep blockade Post-tetanic count (PTC). Data are described by descriptive analytic methods (mean, standard deviation -SD, median). Results: Overall, 291 patients were included in the study. The incidence of RNB in the OR was 48.2 % (95% CI: 42.4 54.1%, n=136) and the incidence of RNB in PACU was 26.9 % (95% CI: 19.5 35.3 %, n = 32). Active block reversal was administered in 23.3% (n=68) patients. Overall, 31.6% (87/275) patients were extubated with TOFr&lt;0.9. Conclusion: Residual neuromuscular blockade in selected cohort of paediatric patients was frequent.

Název v anglickém jazyce

Residual neuromuscular block in paediatric anaesthesia

Popis výsledku anglicky

Background: Residual neuromuscular blockade (RNB) in postoperative period is frequent (26-88%) and it is associated with negative impact on perioperative morbidity. The safety cut-off measured by accelerometry is currently defined as Train-of-four ratio (TOFr) &gt;= 0.9. The primary outcome of the study was detect the incidence of RNB measured just prior extubation in the operating room (OR) (according to pragmatic trial design) and the secondary outcome was the incidence of the RNB in postanaethesia care unit (PACU). Methods: After Ethics Committee (10/2016) approval, paediatric patients (1.1.2017-31.12.2017) undergoing surgery in general anaesthesia with muscle relaxation were included in the study. The level of blockade was measured just prior to extubation in OR (patient eligible for extubation according to the anesthesiologist) and after arrival at PACU with acceleromtery - TOF-Watch(R)SX (Organon, Inc, West Orange, NJ). The mode for measurement was Train-of-four (TOF) and Train-of-four ratio (TOFr), in case of deep blockade Post-tetanic count (PTC). Data are described by descriptive analytic methods (mean, standard deviation -SD, median). Results: Overall, 291 patients were included in the study. The incidence of RNB in the OR was 48.2 % (95% CI: 42.4 54.1%, n=136) and the incidence of RNB in PACU was 26.9 % (95% CI: 19.5 35.3 %, n = 32). Active block reversal was administered in 23.3% (n=68) patients. Overall, 31.6% (87/275) patients were extubated with TOFr&lt;0.9. Conclusion: Residual neuromuscular blockade in selected cohort of paediatric patients was frequent.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30223 - Anaesthesiology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

British Journal Of Anaesthesia

ISSN

0007-0912

e-ISSN

—

Svazek periodika

122

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

2

Strana od-do

"E1"-"E2"

Kód UT WoS článku

000453927600001

EID výsledku v databázi Scopus

2-s2.0-85058663537