The role of the NOD2/CARD15 gene in surgical treatment prediction in patients with Crohn's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00070515" target="_blank" >RIV/65269705:_____/19:00070515 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/19:00108963

Výsledek na webu

<a href="https://link.springer.com/article/10.1007%2Fs00384-018-3122-7" target="_blank" >https://link.springer.com/article/10.1007%2Fs00384-018-3122-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00384-018-3122-7" target="_blank" >10.1007/s00384-018-3122-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of the NOD2/CARD15 gene in surgical treatment prediction in patients with Crohn's disease

Popis výsledku v původním jazyce

PurposeCrohn&apos;s disease (CD) belongs to chronic disorders with unpredictable disease course. The aim of this study was to identify how genetic testing (NOD2/CARD15) can be used in patients with CD to predict the need for surgical treatment (to define an aggressive type of disease where the patient can profit from early surgery).MethodsThe patients who were tested genetically had undergone a surgery due to CD at the Department of Surgery University Hospital Brno Bohunice between 2010 and 2016. The control group consisted of patients with CD who had been diagnosed with CD at least 5years prior to the testing and had not required any surgical intervention. The second control group was healthy subjects.ResultsIn total, there were 117 operated patients for CD, 77 patients with CD that had not undergone surgery for CD and 30 healthy subjects. For patients with at least one genetic mutation, the risk of the necessity of surgical treatment of CD is 1.96 times higher than for patients with no mutation. Patients with two or more mutations were generally operated on at a younger age, in a shorter time after being diagnosed and each patient had a partial resection of the ileum.ConclusionThe group of operated patients with CD had a significantly higher distribution of at least one genetic mutation as opposed to the non-operated group. In patients with two or more mutations, the disease course was more aggressive. This group of patients might profit from the conservative top-down or early surgical therapy.

Název v anglickém jazyce

The role of the NOD2/CARD15 gene in surgical treatment prediction in patients with Crohn's disease

Popis výsledku anglicky

PurposeCrohn&apos;s disease (CD) belongs to chronic disorders with unpredictable disease course. The aim of this study was to identify how genetic testing (NOD2/CARD15) can be used in patients with CD to predict the need for surgical treatment (to define an aggressive type of disease where the patient can profit from early surgery).MethodsThe patients who were tested genetically had undergone a surgery due to CD at the Department of Surgery University Hospital Brno Bohunice between 2010 and 2016. The control group consisted of patients with CD who had been diagnosed with CD at least 5years prior to the testing and had not required any surgical intervention. The second control group was healthy subjects.ResultsIn total, there were 117 operated patients for CD, 77 patients with CD that had not undergone surgery for CD and 30 healthy subjects. For patients with at least one genetic mutation, the risk of the necessity of surgical treatment of CD is 1.96 times higher than for patients with no mutation. Patients with two or more mutations were generally operated on at a younger age, in a shorter time after being diagnosed and each patient had a partial resection of the ileum.ConclusionThe group of operated patients with CD had a significantly higher distribution of at least one genetic mutation as opposed to the non-operated group. In patients with two or more mutations, the disease course was more aggressive. This group of patients might profit from the conservative top-down or early surgical therapy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30212 - Surgery

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Colorectal Disease

ISSN

0179-1958

e-ISSN

—

Svazek periodika

34

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

347-351

Kód UT WoS článku

000455824400018

EID výsledku v databázi Scopus

2-s2.0-85051211787