Quantitative myotonia assessment with a commercially available dynamometer in myotonic dystrophy types 1 and 2

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00070531" target="_blank" >RIV/65269705:_____/19:00070531 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/19:00109475

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/mus.26401" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/mus.26401</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mus.26401" target="_blank" >10.1002/mus.26401</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Quantitative myotonia assessment with a commercially available dynamometer in myotonic dystrophy types 1 and 2

Popis výsledku v původním jazyce

Introduction: The objective of this study was to develop a simple method for quantitative assessment of myotonia in patients with myotonic dystrophy type 1 (DM1) and DM2, to compare the myotonia severity, and to correlate this objective outcome with a subjective scale, the Myotonia Behaviour Scale (MBS). Methods: A commercially available dynamometer was used for all measurements. The relaxation time after voluntary contraction was measured in 20 patients with DM1, 25 patients with DM2, and 35 healthy controls. Results: The average relaxation time was 0.17 s in controls, 2.96 s in patients with DM1, and 0.4 s in patients with DM2. The correlation between relaxation time and MBS score was significant, 0.627 in patients with DM1 and 0.581 in patients with DM2. Discussion: Our method provides a valid and reliable quantitative measure of grip myotonia suitable as an outcome measure in clinical trials and as part of routine examinations to gather data on the natural history of myotonic disorders.

Název v anglickém jazyce

Quantitative myotonia assessment with a commercially available dynamometer in myotonic dystrophy types 1 and 2

Popis výsledku anglicky

Introduction: The objective of this study was to develop a simple method for quantitative assessment of myotonia in patients with myotonic dystrophy type 1 (DM1) and DM2, to compare the myotonia severity, and to correlate this objective outcome with a subjective scale, the Myotonia Behaviour Scale (MBS). Methods: A commercially available dynamometer was used for all measurements. The relaxation time after voluntary contraction was measured in 20 patients with DM1, 25 patients with DM2, and 35 healthy controls. Results: The average relaxation time was 0.17 s in controls, 2.96 s in patients with DM1, and 0.4 s in patients with DM2. The correlation between relaxation time and MBS score was significant, 0.627 in patients with DM1 and 0.581 in patients with DM2. Discussion: Our method provides a valid and reliable quantitative measure of grip myotonia suitable as an outcome measure in clinical trials and as part of routine examinations to gather data on the natural history of myotonic disorders.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Muscle and Nerve

ISSN

0148-639X

e-ISSN

—

Svazek periodika

59

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

431-435

Kód UT WoS článku

000461232700012

EID výsledku v databázi Scopus

2-s2.0-85059669691