Plasma bio-adrenomedullin is a marker of acute heart failure severity in patients with acute coronary syndrome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F19%3A00070542" target="_blank" >RIV/65269705:_____/19:00070542 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/19:00109543

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2352906719300132" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2352906719300132</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcha.2019.02.011" target="_blank" >10.1016/j.ijcha.2019.02.011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Plasma bio-adrenomedullin is a marker of acute heart failure severity in patients with acute coronary syndrome

Popis výsledku v původním jazyce

Background: The assessment of acute heart failure (AHF) in patients with acute coronary syndrome (ACS) is challenging. This study tested whether measuring plasma adrenomedullin in patients admitted for ACS provides valuable information regarding the presence of AHF at admission or its occurrence during hospitalization. Methods and results: The study population consisted of 927 prospectively enrolled patients with ACS. Blood samples for the measurement of plasma bio-adrenomedullin (bio-ADM) were collected at admission. Patients with alveolar pulmonary edema and interstitial pulmonary edema on chest radiography at admission had step-wise higher plasma concentrations of bio-ADM compared to patients with no or mild pulmonary congestion: 54.3 +/- 10.6 vs. 27.6 +/- 2.1 vs. 22.5 +/- 0.7 ng/L, overall P &lt; 0.001. Patients with ACS complicated by AHF during the index hospitalization displayed higher plasma bio-ADM concentrations at admission compared to patients without AHF (33.8 +/- 2.7 vs. 21.8 +/- 0.7, P &lt; 0.001): the higher the severity of AHF, the higher plasma bio-ADM concentrations at admission. Patients with cardiogenic shock displayed the highest values. Accordingly, bio-ADM concentrations at admission were associated with a higher risk of occurrence of AHF during index hospitalization (odds ratio 1.018, 95% confidence interval 1.011-1.026, P &lt; 0.001). Conclusions: Plasma adrenomedullin is a marker associated with AHF severity in patients with ACS.

Název v anglickém jazyce

Plasma bio-adrenomedullin is a marker of acute heart failure severity in patients with acute coronary syndrome

Popis výsledku anglicky

Background: The assessment of acute heart failure (AHF) in patients with acute coronary syndrome (ACS) is challenging. This study tested whether measuring plasma adrenomedullin in patients admitted for ACS provides valuable information regarding the presence of AHF at admission or its occurrence during hospitalization. Methods and results: The study population consisted of 927 prospectively enrolled patients with ACS. Blood samples for the measurement of plasma bio-adrenomedullin (bio-ADM) were collected at admission. Patients with alveolar pulmonary edema and interstitial pulmonary edema on chest radiography at admission had step-wise higher plasma concentrations of bio-ADM compared to patients with no or mild pulmonary congestion: 54.3 +/- 10.6 vs. 27.6 +/- 2.1 vs. 22.5 +/- 0.7 ng/L, overall P &lt; 0.001. Patients with ACS complicated by AHF during the index hospitalization displayed higher plasma bio-ADM concentrations at admission compared to patients without AHF (33.8 +/- 2.7 vs. 21.8 +/- 0.7, P &lt; 0.001): the higher the severity of AHF, the higher plasma bio-ADM concentrations at admission. Patients with cardiogenic shock displayed the highest values. Accordingly, bio-ADM concentrations at admission were associated with a higher risk of occurrence of AHF during index hospitalization (odds ratio 1.018, 95% confidence interval 1.011-1.026, P &lt; 0.001). Conclusions: Plasma adrenomedullin is a marker associated with AHF severity in patients with ACS.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

IJC Heart &amp; Vasculature

ISSN

2352-9067

e-ISSN

—

Svazek periodika

22

Číslo periodika v rámci svazku

MAR 2019

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

3

Strana od-do

174-176

Kód UT WoS článku

000462184100037

EID výsledku v databázi Scopus

2-s2.0-85062494828