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Trophoblast stem cells - Methods of isolation, histological and cellular characteristic, and their possible applications in human and animal models

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F20%3A00074037" target="_blank" >RIV/65269705:_____/20:00074037 - isvavai.cz</a>

  • Výsledek na webu

    <a href="https://www.sciendo.com/article/10.2478/acb-2020-0012" target="_blank" >https://www.sciendo.com/article/10.2478/acb-2020-0012</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2478/acb-2020-0012" target="_blank" >10.2478/acb-2020-0012</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Trophoblast stem cells - Methods of isolation, histological and cellular characteristic, and their possible applications in human and animal models

  • Popis výsledku v původním jazyce

    The placenta is a part of feto-maternal unit that develops from the maternal decidua basalis and fetal-derived trophoblast cells. The regulation of its early development is extremely intricate, albeit the elusive trophoblast stem cells (TSCs) are thought to give rise to the fetal part of the placenta. TSCs may be isolated in both animal and human models. In detail, TSCs can be efficiently obtained from the early conceptus tissues - blastocysts or early placental tissue. The isolation of murine TSCs pave the way for analyses of human trophoblast cell lineages. Both human and animal stem cells retain similar characteristic properties - the ability for unrestricted self-renewal and differentiation into all trophoblast cell lines. Nevertheless, there are some essential differences across the various species which are especially pronounced when pertaining to their distinct optimal cell culture requirements. Moreover, there are several crucial discrepancies in the stemness marker gene transcription profiles between human and murine TSCs models. In vitro TSC models can be adapted to the elucidation of the pathophysiology of various reproductive complications. For instance, their properties may illustrate the conditions observed during the implantation or simulate the state of abnormal placentation. Observations gained from the experimental studies could potentially explain the cause of some cases of infertility, preeclampsia, and fetal growth abnormalities. Running title: Update on the trophoblast stem cells.

  • Název v anglickém jazyce

    Trophoblast stem cells - Methods of isolation, histological and cellular characteristic, and their possible applications in human and animal models

  • Popis výsledku anglicky

    The placenta is a part of feto-maternal unit that develops from the maternal decidua basalis and fetal-derived trophoblast cells. The regulation of its early development is extremely intricate, albeit the elusive trophoblast stem cells (TSCs) are thought to give rise to the fetal part of the placenta. TSCs may be isolated in both animal and human models. In detail, TSCs can be efficiently obtained from the early conceptus tissues - blastocysts or early placental tissue. The isolation of murine TSCs pave the way for analyses of human trophoblast cell lineages. Both human and animal stem cells retain similar characteristic properties - the ability for unrestricted self-renewal and differentiation into all trophoblast cell lines. Nevertheless, there are some essential differences across the various species which are especially pronounced when pertaining to their distinct optimal cell culture requirements. Moreover, there are several crucial discrepancies in the stemness marker gene transcription profiles between human and murine TSCs models. In vitro TSC models can be adapted to the elucidation of the pathophysiology of various reproductive complications. For instance, their properties may illustrate the conditions observed during the implantation or simulate the state of abnormal placentation. Observations gained from the experimental studies could potentially explain the cause of some cases of infertility, preeclampsia, and fetal growth abnormalities. Running title: Update on the trophoblast stem cells.

Klasifikace

  • Druh

    J<sub>SC</sub> - Článek v periodiku v databázi SCOPUS

  • CEP obor

  • OECD FORD obor

    10601 - Cell biology

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2020

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Medical Journal of Cell Biology

  • ISSN

    2544-3577

  • e-ISSN

  • Svazek periodika

    8

  • Číslo periodika v rámci svazku

    3

  • Stát vydavatele periodika

    PL - Polská republika

  • Počet stran výsledku

    6

  • Strana od-do

    95-100

  • Kód UT WoS článku

  • EID výsledku v databázi Scopus

    2-s2.0-85100182741