Recent findings on perinatal mesenchymal stem cells-their possible application in current advanced medicine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074489" target="_blank" >RIV/65269705:_____/21:00074489 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60460709:41210/21:87148 RIV/00216224:14110/21:00123198

Výsledek na webu

<a href="https://sciendo.com/article/10.2478/acb-2021-0008" target="_blank" >https://sciendo.com/article/10.2478/acb-2021-0008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/acb-2021-0008" target="_blank" >10.2478/acb-2021-0008</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Recent findings on perinatal mesenchymal stem cells-their possible application in current advanced medicine

Popis výsledku v původním jazyce

The mature human placenta and umbilical cord are rich sources of perinatal mesenchymal stem cells (MSCs). Both cell populations have similar characteristics and cellular properties. Each population can differentiate into multiple mesenchymal subpopulations and retain their self-renewal capacities. Perinatal stem cells can be isolated from tissues obtained from the planned cesarean sections and vaginal deliveries. Their isolation is relatively easy, making them readily available for implementation in various in vitro studies and clinical trials. Their differentiation abilities could be used in advanced regenerative medicine protocols to form new bone, cartilage, or tendons. Moreover, their unique anti-inflammatory and immunomodulatory properties have been implemented in the experimental treatment of multiple autoimmune and degenerative diseases. Numerous phase I/II clinical trials confirmed the safety of perinatal MSCs injections and infusions, albeit the efficacy of those cellular therapies should be investigated in the subsequent large-scale randomized trials. Running title: Clinical applications of the perinatal mesenchymal stem cells.

Název v anglickém jazyce

Recent findings on perinatal mesenchymal stem cells-their possible application in current advanced medicine

Popis výsledku anglicky

The mature human placenta and umbilical cord are rich sources of perinatal mesenchymal stem cells (MSCs). Both cell populations have similar characteristics and cellular properties. Each population can differentiate into multiple mesenchymal subpopulations and retain their self-renewal capacities. Perinatal stem cells can be isolated from tissues obtained from the planned cesarean sections and vaginal deliveries. Their isolation is relatively easy, making them readily available for implementation in various in vitro studies and clinical trials. Their differentiation abilities could be used in advanced regenerative medicine protocols to form new bone, cartilage, or tendons. Moreover, their unique anti-inflammatory and immunomodulatory properties have been implemented in the experimental treatment of multiple autoimmune and degenerative diseases. Numerous phase I/II clinical trials confirmed the safety of perinatal MSCs injections and infusions, albeit the efficacy of those cellular therapies should be investigated in the subsequent large-scale randomized trials. Running title: Clinical applications of the perinatal mesenchymal stem cells.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medical Journal of Cell Biology

ISSN

2544-3577

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

8

Strana od-do

48-55

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85109154892