Gut microbiota and autism spectrum disorders

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074527" target="_blank" >RIV/65269705:_____/21:00074527 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/21:00124206

Výsledek na webu

<a href="https://www.csnn.eu/casopisy/ceska-slovenska-neurologie/2021-2-9/strevni-mikrobiota-a-poruchy-autistickeho-spektra-127024?hl=en" target="_blank" >https://www.csnn.eu/casopisy/ceska-slovenska-neurologie/2021-2-9/strevni-mikrobiota-a-poruchy-autistickeho-spektra-127024?hl=en</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.48095/cccsnn2021127" target="_blank" >10.48095/cccsnn2021127</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gut microbiota and autism spectrum disorders

Popis výsledku v původním jazyce

Autism spectrum disorders (ASD) are neurodevelopmental and neuropsychiatric disorders with clinical manifestation in childhood, characterized by difficulties in social interaction and communication, limited interests, and repetitive behavior. In recent years, there has been a significant increase in the prevalence of this disorder, currently affecting 1-2% of children. In pathophysiology, genetic factors are mainly used, which are also modified in their phenotypic expression by environmental factors. A large percentage of patients with ASD also have a variety of gastrointestinal problems; children experience constipation or diarrhea, flatulence, or nonspecific abdominal pain. In last years, the connection of intestinal symptomatology with the manifestations of ASD has come to the forefront of scientific interest with the development of new molecular-biological methods of studying the community of intestinal microorganisms, the gut microbiota. Communication between the gut and the CNS (the gut-brain axis) is made possible by a very complex two-way neurohumoral communication system. This system ensures the effect of the intestinal microbiota on brain functions and allows the brain signals to affect the intestinal microbiota activity and the gastrointestinal tract functions. This article focuses on various pathophysiological mechanisms involved in these processes and discusses in detail the possible therapeutic modalities that affect the gut microbiota composition and function, such as the use of vancomycin, oxytocin, prebiotics and probiotics, as well as fecal transplantation, which has very promising results in relation to both gastrointestinal and ASD symptoms.

Název v anglickém jazyce

Gut microbiota and autism spectrum disorders

Popis výsledku anglicky

Autism spectrum disorders (ASD) are neurodevelopmental and neuropsychiatric disorders with clinical manifestation in childhood, characterized by difficulties in social interaction and communication, limited interests, and repetitive behavior. In recent years, there has been a significant increase in the prevalence of this disorder, currently affecting 1-2% of children. In pathophysiology, genetic factors are mainly used, which are also modified in their phenotypic expression by environmental factors. A large percentage of patients with ASD also have a variety of gastrointestinal problems; children experience constipation or diarrhea, flatulence, or nonspecific abdominal pain. In last years, the connection of intestinal symptomatology with the manifestations of ASD has come to the forefront of scientific interest with the development of new molecular-biological methods of studying the community of intestinal microorganisms, the gut microbiota. Communication between the gut and the CNS (the gut-brain axis) is made possible by a very complex two-way neurohumoral communication system. This system ensures the effect of the intestinal microbiota on brain functions and allows the brain signals to affect the intestinal microbiota activity and the gastrointestinal tract functions. This article focuses on various pathophysiological mechanisms involved in these processes and discusses in detail the possible therapeutic modalities that affect the gut microbiota composition and function, such as the use of vancomycin, oxytocin, prebiotics and probiotics, as well as fecal transplantation, which has very promising results in relation to both gastrointestinal and ASD symptoms.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

—

Svazek periodika

84

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

8

Strana od-do

127-134

Kód UT WoS článku

000694710200002

EID výsledku v databázi Scopus

2-s2.0-85108081970