Hybrid argon plasma coagulation in the ablation treatment of Barrett´s esophagus - long term results

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00074796" target="_blank" >RIV/65269705:_____/21:00074796 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1002/ueg2.12144" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/ueg2.12144</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Hybrid argon plasma coagulation in the ablation treatment of Barrett´s esophagus - long term results

Popis výsledku v původním jazyce

Introduction As an alternative to radiofrequency ablation (RFA), combined use of argon plasma coagulation with prior submucosal injection (hybrid APC) had been used successfully for ablation of dysplastic or residual intestinal metaplasia (IM) in Barrett&apos;s esophagus (BE). Our study aims to analyze 24 months follow up results of hybrid APC in BE. Aims &amp; Methods Single center prospective study included patients with BE with dysplasia either without visible lesion or with visible lesion after prior endoscopic resection for ablation of residual BE during years 2017-2018. The extent of BE was limited to maximal 5 cm length. Hybrid APC (ERBE) was done during sedated endoscopy up to 3 sessions in 2-3 months intervals. Follow up by endoscopy with biopsy was regularly performed in 6 months intervals. All patients received regular proton pump inhibitor therapy. Results From 28 included patients, 24 patients (mean age 60 years, 79 % male) were available for analysis 2 years after intervention. In 7 patients previous endoscopic resection of visible lesion with dysplasia or early cancer was done. Mean 1.5 hybrid APC procedures were performed per patient to get optimal endoscopic result. In 24 months, histologic absence of dysplasia was achieved in 22/24 (92 %). Endoscopic and histologic absence of IM was achieved in 21/24 (88 %) and 18/24 (75 %) respectively. In 5 patients nonvisible IM was detected by biopsy, while a small visible abnormality without confirmed IM was seen in 2 patients. The main procedure related symptoms were pain and dysphagia in 62 % and 16 % respectively. Stricture developed in 1/24 (4 %). No perforation or bleeding occurred. Conclusion Hybrid APC seems an effective, safe and easy method in the ablation of short segment BE either in nonvisible dysplasia or residual IM after endoscopic resection. However, repetitive procedures and follow up are required.

Název v anglickém jazyce

Hybrid argon plasma coagulation in the ablation treatment of Barrett´s esophagus - long term results

Popis výsledku anglicky

Introduction As an alternative to radiofrequency ablation (RFA), combined use of argon plasma coagulation with prior submucosal injection (hybrid APC) had been used successfully for ablation of dysplastic or residual intestinal metaplasia (IM) in Barrett&apos;s esophagus (BE). Our study aims to analyze 24 months follow up results of hybrid APC in BE. Aims &amp; Methods Single center prospective study included patients with BE with dysplasia either without visible lesion or with visible lesion after prior endoscopic resection for ablation of residual BE during years 2017-2018. The extent of BE was limited to maximal 5 cm length. Hybrid APC (ERBE) was done during sedated endoscopy up to 3 sessions in 2-3 months intervals. Follow up by endoscopy with biopsy was regularly performed in 6 months intervals. All patients received regular proton pump inhibitor therapy. Results From 28 included patients, 24 patients (mean age 60 years, 79 % male) were available for analysis 2 years after intervention. In 7 patients previous endoscopic resection of visible lesion with dysplasia or early cancer was done. Mean 1.5 hybrid APC procedures were performed per patient to get optimal endoscopic result. In 24 months, histologic absence of dysplasia was achieved in 22/24 (92 %). Endoscopic and histologic absence of IM was achieved in 21/24 (88 %) and 18/24 (75 %) respectively. In 5 patients nonvisible IM was detected by biopsy, while a small visible abnormality without confirmed IM was seen in 2 patients. The main procedure related symptoms were pain and dysphagia in 62 % and 16 % respectively. Stricture developed in 1/24 (4 %). No perforation or bleeding occurred. Conclusion Hybrid APC seems an effective, safe and easy method in the ablation of short segment BE either in nonvisible dysplasia or residual IM after endoscopic resection. However, repetitive procedures and follow up are required.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů