GAB1 – Novel Regulator of Migration Capacity and Tonic AKT Activity in CLL: Implications for Combinatorial Therapy With BCR Inhibitors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00075055" target="_blank" >RIV/65269705:_____/21:00075055 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.tandfonline.com/doi/abs/10.1080/10428194.2021.1995175" target="_blank" >https://www.tandfonline.com/doi/abs/10.1080/10428194.2021.1995175</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/10428194.2021.1995175" target="_blank" >10.1080/10428194.2021.1995175</a>

Jazyk výsledku

angličtina

Název v původním jazyce

GAB1 – Novel Regulator of Migration Capacity and Tonic AKT Activity in CLL: Implications for Combinatorial Therapy With BCR Inhibitors

Popis výsledku v původním jazyce

Introduction: CLL cell recirculation between peripheral blood and immune niches has been proposed as an important feature of CLL pathophysiology. However, it remains unknown how precisely CLL cells regulate their homing or how they balance survival in peripheral blood and the decision to return to immune niches. It has been hypothesized that the CLL cell recirculation can be studied by analyzing CXCR4/CD5 intraclonal CLL subpopulations (Calissano et al., 2011; Pavlasova et al., 2016). Here, we aim to identify and functionally characterize novel regulators of CLL cell migration.

Název v anglickém jazyce

GAB1 – Novel Regulator of Migration Capacity and Tonic AKT Activity in CLL: Implications for Combinatorial Therapy With BCR Inhibitors

Popis výsledku anglicky

Introduction: CLL cell recirculation between peripheral blood and immune niches has been proposed as an important feature of CLL pathophysiology. However, it remains unknown how precisely CLL cells regulate their homing or how they balance survival in peripheral blood and the decision to return to immune niches. It has been hypothesized that the CLL cell recirculation can be studied by analyzing CXCR4/CD5 intraclonal CLL subpopulations (Calissano et al., 2011; Pavlasova et al., 2016). Here, we aim to identify and functionally characterize novel regulators of CLL cell migration.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

30204 - Oncology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů