Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F21%3A00075828" target="_blank" >RIV/65269705:_____/21:00075828 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/21:00124015

Výsledek na webu

<a href="https://www.mdpi.com/2076-3921/10/12/1886" target="_blank" >https://www.mdpi.com/2076-3921/10/12/1886</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/antiox10121886" target="_blank" >10.3390/antiox10121886</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke

Popis výsledku v původním jazyce

The production of free radicals is inevitably associated with metabolism and other enzymatic processes. Under physiological conditions, however, free radicals are effectively eliminated by numerous antioxidant mechanisms. Oxidative stress occurs due to an imbalance between the production and elimination of free radicals under pathological conditions. Oxidative stress is also associated with ageing. The brain is prone to oxidative damage because of its high metabolic activity and high vulnerability to ischemic damage. Oxidative stress, thus, plays a major role in the pathophysiology of both acute and chronic pathologies in the brain, such as stroke, traumatic brain injury or neurodegenerative diseases. The goal of this article is to summarize the basic concepts of oxidative stress and its significance in brain pathologies, as well as to discuss treatment strategies for dealing with oxidative stress in stroke.

Název v anglickém jazyce

Oxidative Stress in the Brain: Basic Concepts and Treatment Strategies in Stroke

Popis výsledku anglicky

The production of free radicals is inevitably associated with metabolism and other enzymatic processes. Under physiological conditions, however, free radicals are effectively eliminated by numerous antioxidant mechanisms. Oxidative stress occurs due to an imbalance between the production and elimination of free radicals under pathological conditions. Oxidative stress is also associated with ageing. The brain is prone to oxidative damage because of its high metabolic activity and high vulnerability to ischemic damage. Oxidative stress, thus, plays a major role in the pathophysiology of both acute and chronic pathologies in the brain, such as stroke, traumatic brain injury or neurodegenerative diseases. The goal of this article is to summarize the basic concepts of oxidative stress and its significance in brain pathologies, as well as to discuss treatment strategies for dealing with oxidative stress in stroke.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Antioxidants

ISSN

2076-3921

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

12

Strana od-do

1886

Kód UT WoS článku

000735841100001

EID výsledku v databázi Scopus

2-s2.0-85119895192