Primary progressive multiple sclerosis overlapping with anti-GAD and anti-Hu antibodies positive neurological syndromes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F22%3A00076140" target="_blank" >RIV/65269705:_____/22:00076140 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/22:10444210 RIV/00179906:_____/22:10444210 RIV/00216224:14110/22:00128220

Výsledek na webu

<a href="https://journals.viamedica.pl/neurologia_neurochirurgia_polska/article/view/83418" target="_blank" >https://journals.viamedica.pl/neurologia_neurochirurgia_polska/article/view/83418</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5603/PJNNS.a2021.0078" target="_blank" >10.5603/PJNNS.a2021.0078</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Primary progressive multiple sclerosis overlapping with anti-GAD and anti-Hu antibodies positive neurological syndromes

Popis výsledku v původním jazyce

Although still rare, there have been reports describing autoimmune demyelinating disorders associated with specific antibodies which overlap with multiple sclerosis (MS) and other demyelinating syndromes in clinical, radiological and immunological features. A relationship between anti-myelin-associated glycoprotein (MOG) syndrome, anti-aquaporin-4 (AQ-4) neuromyelitis optica spectrum disorders, and anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis has been described. The opportunity of discovering yet unknown associations is based on the presumption of the co-occurrence of immune mediated diseases [1]. The association of multiple sclerosis with glutamic acid decarboxylase (GAD) neurological syndromes has only been reported in one case [2, 3]. The associated neurological syndromes include stiff-person syndrome (SPS), cerebellar ataxia, epilepsy, and limbic encephalitis. Paraneoplastic origin is rare, and comorbidities include autoimmune thyreoiditis, pernicious anaemia and vitiligo [4]. More than 85% of patients with anti-Hu antibodies harbour small cell lung cancer (SCLC) or, less frequently, other tumours. Anti-Hu antibodies can be found in the sera of 2% of patients without a tumour after five years, but these antibodies are not detected in normal subjects or in other neurological disorders [5]. We present one case of non-paraneoplastic anti-Hu brainstem syndrome and one case of progressive GAD ataxia syndrome associated with primary progressive multiple sclerosis (PP-MS).

Název v anglickém jazyce

Primary progressive multiple sclerosis overlapping with anti-GAD and anti-Hu antibodies positive neurological syndromes

Popis výsledku anglicky

Although still rare, there have been reports describing autoimmune demyelinating disorders associated with specific antibodies which overlap with multiple sclerosis (MS) and other demyelinating syndromes in clinical, radiological and immunological features. A relationship between anti-myelin-associated glycoprotein (MOG) syndrome, anti-aquaporin-4 (AQ-4) neuromyelitis optica spectrum disorders, and anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis has been described. The opportunity of discovering yet unknown associations is based on the presumption of the co-occurrence of immune mediated diseases [1]. The association of multiple sclerosis with glutamic acid decarboxylase (GAD) neurological syndromes has only been reported in one case [2, 3]. The associated neurological syndromes include stiff-person syndrome (SPS), cerebellar ataxia, epilepsy, and limbic encephalitis. Paraneoplastic origin is rare, and comorbidities include autoimmune thyreoiditis, pernicious anaemia and vitiligo [4]. More than 85% of patients with anti-Hu antibodies harbour small cell lung cancer (SCLC) or, less frequently, other tumours. Anti-Hu antibodies can be found in the sera of 2% of patients without a tumour after five years, but these antibodies are not detected in normal subjects or in other neurological disorders [5]. We present one case of non-paraneoplastic anti-Hu brainstem syndrome and one case of progressive GAD ataxia syndrome associated with primary progressive multiple sclerosis (PP-MS).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neurologia i Neurochirurgia Polska

ISSN

0028-3843

e-ISSN

1897-4260

Svazek periodika

56

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

4

Strana od-do

187-190

Kód UT WoS článku

000793942800001

EID výsledku v databázi Scopus

2-s2.0-85129780993