Evaluating Magnetic Resonance Diffusion Properties Together with Brain Volumetry May Predict Progression to Multiple Sclerosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F22%3A00076582" target="_blank" >RIV/65269705:_____/22:00076582 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/22:00129729

Výsledek na webu

<a href="https://reader.elsevier.com/reader/sd/pii/S1076633221005766?token=9566E4D6E40B30B62F4934C1079AA62E41F6F046CF79B1D10DD701822B1D0ED4467D5735C28CD9DDB9E57B7DBEF7E3A3&originRegion=eu-west-1&originCreation=20230105092920" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S1076633221005766?token=9566E4D6E40B30B62F4934C1079AA62E41F6F046CF79B1D10DD701822B1D0ED4467D5735C28CD9DDB9E57B7DBEF7E3A3&originRegion=eu-west-1&originCreation=20230105092920</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.acra.2021.12.015" target="_blank" >10.1016/j.acra.2021.12.015</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluating Magnetic Resonance Diffusion Properties Together with Brain Volumetry May Predict Progression to Multiple Sclerosis

Popis výsledku v původním jazyce

Rationale and Objectives: Although the gold standard in predicting future progression from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) consists in the McDonald criteria, efforts are being made to employ various advanced MRI techniques for predicting clinical progression. This study&apos;s main aim was to evaluate the predictive power of diffusion tensor imaging (DTI) of the brain and brain volumetry to distinguish between patients having CIS with future progression to CDMS from those without progression during the following 2 years and to compare those parameters with conventional MRI evaluation. Materials and Methods: All participants underwent an MRI scan of the brain. DTI and volumetric data were processed and various parameters were compared between the study groups. Results: We found significant differences between the subgroups of patients differing by future progression to CDMS in most of those DTI and volumetric parameters measured. Fractional anisotropy of water diffusion proved to be the strongest predictor of clinical conversion among all parameters evaluated, demonstrating also higher specificity compared to evaluation of conventional MRI images according to McDonald criteria. Conclusion: Conclusion: Our results provide evidence that the evaluation of DTI parameters together with brain volumetry in patients with early-stage CIS may be useful in predicting conversion to CDMS within the following 2 years of the disease course.

Název v anglickém jazyce

Evaluating Magnetic Resonance Diffusion Properties Together with Brain Volumetry May Predict Progression to Multiple Sclerosis

Popis výsledku anglicky

Rationale and Objectives: Although the gold standard in predicting future progression from clinically isolated syndrome (CIS) to clinically definite multiple sclerosis (CDMS) consists in the McDonald criteria, efforts are being made to employ various advanced MRI techniques for predicting clinical progression. This study&apos;s main aim was to evaluate the predictive power of diffusion tensor imaging (DTI) of the brain and brain volumetry to distinguish between patients having CIS with future progression to CDMS from those without progression during the following 2 years and to compare those parameters with conventional MRI evaluation. Materials and Methods: All participants underwent an MRI scan of the brain. DTI and volumetric data were processed and various parameters were compared between the study groups. Results: We found significant differences between the subgroups of patients differing by future progression to CDMS in most of those DTI and volumetric parameters measured. Fractional anisotropy of water diffusion proved to be the strongest predictor of clinical conversion among all parameters evaluated, demonstrating also higher specificity compared to evaluation of conventional MRI images according to McDonald criteria. Conclusion: Conclusion: Our results provide evidence that the evaluation of DTI parameters together with brain volumetry in patients with early-stage CIS may be useful in predicting conversion to CDMS within the following 2 years of the disease course.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

<a href="/cs/project/NV15-32133A" target="_blank" >NV15-32133A: Predikce konverze klinicky izolovaného syndromu do roztroušené sklerózy pomocí pokročilých technik zobrazení magnetickou rezonancí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACADEMIC RADIOLOGY

ISSN

1076-6332

e-ISSN

1878-4046

Svazek periodika

29

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

1493-1501

Kód UT WoS článku

000892872500010

EID výsledku v databázi Scopus

2-s2.0-85123201217