Cardiovascular Diseases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F23%3A00077971" target="_blank" >RIV/65269705:_____/23:00077971 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/23:00130296

Výsledek na webu

<a href="https://www.degruyter.com/document/doi/10.1515/9783110989380/html" target="_blank" >https://www.degruyter.com/document/doi/10.1515/9783110989380/html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/9783110989380" target="_blank" >10.1515/9783110989380</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cardiovascular Diseases

Popis výsledku v původním jazyce

Cardiovascular diseases (CVDs) are the principal cause of death globally contributing to more than half of the mortality in Europe (42% on males and 51% on females) (RIGHTWARDS ARROWGillespie et al., 2013, RIGHTWARDS ARROWMozaffarian et al., 2015). There is growing interest in studying etiology, hallmarks, progress, and improved therapies for CVDs. Genetic background and cellular phenotypes are frequent morbidity and mortality causes (RIGHTWARDS ARROWAistrup et al., 2009, RIGHTWARDS ARROWStienen, 2015, RIGHTWARDS ARROWvan der Velden and Stienen, 2019), but those are not readily accessible for diagnostics. Stem-cellderived cardiomyocytes (CMs) thus stands for readily available and ethically uncompromised model for basic research. CMs represent the contractile active unit of the heart. Nevertheless, other cardiac cell populations are attracting research interest, for instance endothelial cells (ECs), lining of the heart and vessels, cardiac fibroblasts, accounting mainly for extracellular matrix homeostasis, pericardial, adventitial, and smooth muscle cells. The extracellular matrix (ECM) plays an important role in the cardiovascular system, as mechanical cues are detected and interpreted in a constant cell-matrix interplay (RIGHTWARDS ARROWNardone, Oliver-De La Cruz et al. 2017), and ECM is discussed in Chapter 4.5.The mechanical properties of cells can be used to distinguish pathological from normal cells and tissues in many diseases, not only those where the relation between mechanics and physiology of the disease is obvious, like infarcted heart tissue, but also those where this relation is less obvious or still unknown, like cancer. This book outlines the physics behind cell and tissue mechanics, describes the methods, which can be used to determine the mechanical properties of single cells and tissues, and presents various diseases, in which a mechanical fingerprint could be established. Cell mechanics has the potential to serve as an assay, which could be widely used in the future. This book aims to introduce this topic to researchers from backgrounds as varied as biophysics, biomedical engineering, biotechnology, as well as graduate students from biology to medicine to introducethis novel and exciting concept to the community. In this book, we introduce to several aspects of cell biology, emphasizing the importance of the cytoskeleton, the cell membrane and glycocalyx, and the extracellular matrix. One chapter introduces the physics of continuum mechanics and its application to cells, including viscoelastic measurements. Then, various methods for measuring the mechanical properties of cells and tissues are discussed. Finally, evidence on the mechanical fingerprint of diseases is presented, discussing the properties of pathological cells from cancer, muscular dystrophy to diabetes, to name just a few here. The first volume presents a comprehensive description of the basic concepts of soft matter mechanics and of the nano- and microscale biomedical methods that characterize the mechanical properties of cells and tissues. The second volume is dedicated to discussing several biomedical applications of the mechanical phenotyping of cells and tissues to specific disease models. The topical chapters on mechanics in disease are preceded by chapters describing cell and tissue structure and their relationship with the biomechanical properties, as well as by describing dedicated sample preparation methods for the nano- and microscale mechanical measurements. This book has been written for the primary benefit of young researchers but also of senior scientists, involved in interdisciplinary studies at the boundary of Physics, Biology and Medicine, and committed to transforming academic scientific and technological knowledge into useful diagnostic tools in the clinic. We like to thank all authors of the various chapters for their valuable contributions. We appreciate very much your efforts and your continuing support over the time needed to create this work.

Název v anglickém jazyce

Cardiovascular Diseases

Popis výsledku anglicky

Cardiovascular diseases (CVDs) are the principal cause of death globally contributing to more than half of the mortality in Europe (42% on males and 51% on females) (RIGHTWARDS ARROWGillespie et al., 2013, RIGHTWARDS ARROWMozaffarian et al., 2015). There is growing interest in studying etiology, hallmarks, progress, and improved therapies for CVDs. Genetic background and cellular phenotypes are frequent morbidity and mortality causes (RIGHTWARDS ARROWAistrup et al., 2009, RIGHTWARDS ARROWStienen, 2015, RIGHTWARDS ARROWvan der Velden and Stienen, 2019), but those are not readily accessible for diagnostics. Stem-cellderived cardiomyocytes (CMs) thus stands for readily available and ethically uncompromised model for basic research. CMs represent the contractile active unit of the heart. Nevertheless, other cardiac cell populations are attracting research interest, for instance endothelial cells (ECs), lining of the heart and vessels, cardiac fibroblasts, accounting mainly for extracellular matrix homeostasis, pericardial, adventitial, and smooth muscle cells. The extracellular matrix (ECM) plays an important role in the cardiovascular system, as mechanical cues are detected and interpreted in a constant cell-matrix interplay (RIGHTWARDS ARROWNardone, Oliver-De La Cruz et al. 2017), and ECM is discussed in Chapter 4.5.The mechanical properties of cells can be used to distinguish pathological from normal cells and tissues in many diseases, not only those where the relation between mechanics and physiology of the disease is obvious, like infarcted heart tissue, but also those where this relation is less obvious or still unknown, like cancer. This book outlines the physics behind cell and tissue mechanics, describes the methods, which can be used to determine the mechanical properties of single cells and tissues, and presents various diseases, in which a mechanical fingerprint could be established. Cell mechanics has the potential to serve as an assay, which could be widely used in the future. This book aims to introduce this topic to researchers from backgrounds as varied as biophysics, biomedical engineering, biotechnology, as well as graduate students from biology to medicine to introducethis novel and exciting concept to the community. In this book, we introduce to several aspects of cell biology, emphasizing the importance of the cytoskeleton, the cell membrane and glycocalyx, and the extracellular matrix. One chapter introduces the physics of continuum mechanics and its application to cells, including viscoelastic measurements. Then, various methods for measuring the mechanical properties of cells and tissues are discussed. Finally, evidence on the mechanical fingerprint of diseases is presented, discussing the properties of pathological cells from cancer, muscular dystrophy to diabetes, to name just a few here. The first volume presents a comprehensive description of the basic concepts of soft matter mechanics and of the nano- and microscale biomedical methods that characterize the mechanical properties of cells and tissues. The second volume is dedicated to discussing several biomedical applications of the mechanical phenotyping of cells and tissues to specific disease models. The topical chapters on mechanics in disease are preceded by chapters describing cell and tissue structure and their relationship with the biomechanical properties, as well as by describing dedicated sample preparation methods for the nano- and microscale mechanical measurements. This book has been written for the primary benefit of young researchers but also of senior scientists, involved in interdisciplinary studies at the boundary of Physics, Biology and Medicine, and committed to transforming academic scientific and technological knowledge into useful diagnostic tools in the clinic. We like to thank all authors of the various chapters for their valuable contributions. We appreciate very much your efforts and your continuing support over the time needed to create this work.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Mechanics of Cells and Tissues in Diseases: Biomedical Applications: Volume 2

ISBN

978-3-11-099972-3

Počet stran výsledku

24

Strana od-do

1-24

Počet stran knihy

352

Název nakladatele

Walter de Gruyter

Místo vydání

Berlin

Kód UT WoS kapitoly

—