Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F23%3A00078509" target="_blank" >RIV/65269705:_____/23:00078509 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/23:00132253

Výsledek na webu

<a href="https://bmjpaedsopen.bmj.com/content/bmjpo/7/1/e002172.full.pdf" target="_blank" >https://bmjpaedsopen.bmj.com/content/bmjpo/7/1/e002172.full.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/bmjpo-2023-002172" target="_blank" >10.1136/bmjpo-2023-002172</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates

Popis výsledku v původním jazyce

Although necrotising enterocolitis (NEC) is a serious, life-threatening disease, improved neonatal care is increasing the number of survivors with NEC among extremely preterm neonates. Therapy is nevertheless mostly symptomatic and the mortality rate remains high, especially among neonates requiring surgery. Therefore, it is important to focus on preventing the disease and modifiable risk factors. NEC&apos;s pathophysiology is multifaceted, with key factors being immaturity of the immune and barrier protective mechanisms of the premature gut and exaggerated proinflammatory reaction to insults like gut hypoxia, enteral nutrition or microbial dysbiosis. The role of the intestinal microbiome in the pathophysiology of NEC has been a subject of research for many years, but to date no specific pathogen or type of dysbiosis has been connected with NEC development. This review assesses current knowledge as to the role of the intestinal microbiota in the pathophysiology of NEC and the possibilities for positively influencing it

Název v anglickém jazyce

Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates

Popis výsledku anglicky

Although necrotising enterocolitis (NEC) is a serious, life-threatening disease, improved neonatal care is increasing the number of survivors with NEC among extremely preterm neonates. Therapy is nevertheless mostly symptomatic and the mortality rate remains high, especially among neonates requiring surgery. Therefore, it is important to focus on preventing the disease and modifiable risk factors. NEC&apos;s pathophysiology is multifaceted, with key factors being immaturity of the immune and barrier protective mechanisms of the premature gut and exaggerated proinflammatory reaction to insults like gut hypoxia, enteral nutrition or microbial dysbiosis. The role of the intestinal microbiome in the pathophysiology of NEC has been a subject of research for many years, but to date no specific pathogen or type of dysbiosis has been connected with NEC development. This review assesses current knowledge as to the role of the intestinal microbiota in the pathophysiology of NEC and the possibilities for positively influencing it

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMJ Paediatrics Open

ISSN

2399-9772

e-ISSN

2399-9772

Svazek periodika

7

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

"e002172"

Kód UT WoS článku

001099840500001

EID výsledku v databázi Scopus

2-s2.0-85177452191