Risk factors and the severity of defect in patients with cleft lip and palate

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F24%3A00079896" target="_blank" >RIV/65269705:_____/24:00079896 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/24:00136427

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0165587624001216?pes=vor" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0165587624001216?pes=vor</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijporl.2024.111967" target="_blank" >10.1016/j.ijporl.2024.111967</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Risk factors and the severity of defect in patients with cleft lip and palate

Popis výsledku v původním jazyce

Orofacial clefts are one of the most common congenital malformations worldwide. The incidence of the newborns with orofacial clefts is approximately 1.7 in 1000 live births [1] and varies across regions, ethnicities, risk factors, and other variables. In the Czech Republic, the incidence is one cleft child in 600 healthy newborns [2]. Patients with cleft have higher mortality and morbidity than those without cleft [3,4]. Orofacial clefts have been extensively reviewed in previous literature [5]; the most common are nonsyndromic clefts [6] including cleft lip and palate (CLP), cleft lip (CL), and cleft palate (CP) alone [5]. According to a large European study, 71 % of cleft lip with or without cleft palate (CL/P) cases were isolated, whereas 29 % were linked to other anomalies. Associated malformations are more often reported in patients with CLP (34.0 %) than patients with CL (20.8 %) [7].Etiology of the orofacial clefts is multifactorial: both genetic and environmental factors can contribute to the disease [6]. Previous studies showed that smoking and alcohol or drug consumption during pregnancy, maternal obesity and diabetes, increased maternal and paternal age, and maternal exposure to air and water pollution during pregnancy can increase a child&apos;s risk of developing a cleft [8]. However, the impact of risk factors on the severity of cleft defects remains poorly understood.The aims of this study were to describe the epidemiological data of patients with CL/P who underwent CL surgery in the Cleft Center at the University Hospital Brno (UHB) from 2010 to 2020 and to assess the impact of various risk factors on cleft severity in patients with nonsyndromic CL/P.

Název v anglickém jazyce

Risk factors and the severity of defect in patients with cleft lip and palate

Popis výsledku anglicky

Orofacial clefts are one of the most common congenital malformations worldwide. The incidence of the newborns with orofacial clefts is approximately 1.7 in 1000 live births [1] and varies across regions, ethnicities, risk factors, and other variables. In the Czech Republic, the incidence is one cleft child in 600 healthy newborns [2]. Patients with cleft have higher mortality and morbidity than those without cleft [3,4]. Orofacial clefts have been extensively reviewed in previous literature [5]; the most common are nonsyndromic clefts [6] including cleft lip and palate (CLP), cleft lip (CL), and cleft palate (CP) alone [5]. According to a large European study, 71 % of cleft lip with or without cleft palate (CL/P) cases were isolated, whereas 29 % were linked to other anomalies. Associated malformations are more often reported in patients with CLP (34.0 %) than patients with CL (20.8 %) [7].Etiology of the orofacial clefts is multifactorial: both genetic and environmental factors can contribute to the disease [6]. Previous studies showed that smoking and alcohol or drug consumption during pregnancy, maternal obesity and diabetes, increased maternal and paternal age, and maternal exposure to air and water pollution during pregnancy can increase a child&apos;s risk of developing a cleft [8]. However, the impact of risk factors on the severity of cleft defects remains poorly understood.The aims of this study were to describe the epidemiological data of patients with CL/P who underwent CL surgery in the Cleft Center at the University Hospital Brno (UHB) from 2010 to 2020 and to assess the impact of various risk factors on cleft severity in patients with nonsyndromic CL/P.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Pediatric Otorhinolaryngology

ISSN

0165-5876

e-ISSN

1872-8464

Svazek periodika

181

Číslo periodika v rámci svazku

JUN 2024

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

5

Strana od-do

111967

Kód UT WoS článku

001244431100001

EID výsledku v databázi Scopus

2-s2.0-85193425833