Quantitative magnetic resonance imaging parameters of lumbar paraspinal muscles and their relationship to function and ageing in healthy subjects

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F25%3A00082198" target="_blank" >RIV/65269705:_____/25:00082198 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00141503

Výsledek na webu

<a href="https://qims.amegroups.org/article/view/139108/html" target="_blank" >https://qims.amegroups.org/article/view/139108/html</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.21037/qims-2024-2633" target="_blank" >10.21037/qims-2024-2633</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Quantitative magnetic resonance imaging parameters of lumbar paraspinal muscles and their relationship to function and ageing in healthy subjects

Popis výsledku v původním jazyce

Muscle ageing involves structural and functional changes of muscles, mainly their replacement by fatty and fibrous tissue accompanied by the loss of muscle function. Quantitative magnetic resonance imaging (qMRI) methods have potential to provide biomarkers of degenerative changes in muscles with ageing. To assess the relationship between qMRI parameters of lumbar paraspinal muscles (LPMs) and their function and evolution with ageing in healthy subjects, 90 volunteers underwent MRI of lumbar spine and LPM utilising a 6-point Dixon gradient echo sequence. Using manual muscle segmentation, fat fraction (FF) and functional muscle volume (FMV) were calculated for LPM, with the psoas muscle (PS) as a control muscle. Functional parameters of LPM (strength and endurance) were assessed. Based on our data analysis, both FF and FMV of LPM correlate significantly with maximal isometric lumbar extensor muscle strength, but not with endurance. With ageing, FF of LPM increases by 34% per decade, while FF of PS increases by 17% per decade. This difference between LPM and the PS in the rate of FF increase is significant. FMV evinces a decreasing trend in both LPM and PS. However, only FMV of PS decreases significantly by 7% per decade. Our cross-sectional study shows a significant correlation between qMRI parameters of LPM and their strength. FF appears to be a biomarker of muscle ageing with different ageing patterns of distinct muscle groups: LPM and PS.

Název v anglickém jazyce

Quantitative magnetic resonance imaging parameters of lumbar paraspinal muscles and their relationship to function and ageing in healthy subjects

Popis výsledku anglicky

Muscle ageing involves structural and functional changes of muscles, mainly their replacement by fatty and fibrous tissue accompanied by the loss of muscle function. Quantitative magnetic resonance imaging (qMRI) methods have potential to provide biomarkers of degenerative changes in muscles with ageing. To assess the relationship between qMRI parameters of lumbar paraspinal muscles (LPMs) and their function and evolution with ageing in healthy subjects, 90 volunteers underwent MRI of lumbar spine and LPM utilising a 6-point Dixon gradient echo sequence. Using manual muscle segmentation, fat fraction (FF) and functional muscle volume (FMV) were calculated for LPM, with the psoas muscle (PS) as a control muscle. Functional parameters of LPM (strength and endurance) were assessed. Based on our data analysis, both FF and FMV of LPM correlate significantly with maximal isometric lumbar extensor muscle strength, but not with endurance. With ageing, FF of LPM increases by 34% per decade, while FF of PS increases by 17% per decade. This difference between LPM and the PS in the rate of FF increase is significant. FMV evinces a decreasing trend in both LPM and PS. However, only FMV of PS decreases significantly by 7% per decade. Our cross-sectional study shows a significant correlation between qMRI parameters of LPM and their strength. FF appears to be a biomarker of muscle ageing with different ageing patterns of distinct muscle groups: LPM and PS.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Quantitative Imaging in Medicine and Surgery

ISSN

2223-4292

e-ISSN

2223-4306

Svazek periodika

15

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

CN - Čínská lidová republika

Počet stran výsledku

9

Strana od-do

6517-6525

Kód UT WoS článku

001547700200041

EID výsledku v databázi Scopus

2-s2.0-105009763642