Structural and Functional Outcomes of Optic Pathway Compression in Pituitary Adenoma: A Prospective Pilot OCT Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F25%3A00083295" target="_blank" >RIV/65269705:_____/25:00083295 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00142919

Výsledek na webu

<a href="https://www.tandfonline.com/doi/full/10.2147/OPTH.S556193" target="_blank" >https://www.tandfonline.com/doi/full/10.2147/OPTH.S556193</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/OPTH.S556193" target="_blank" >10.2147/OPTH.S556193</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Structural and Functional Outcomes of Optic Pathway Compression in Pituitary Adenoma: A Prospective Pilot OCT Study

Popis výsledku v původním jazyce

Purpose: To evaluate the anatomical and functional effects of optic chiasm compression caused by a pituitary adenoma both before and after surgery.Patients and Methods: Short-term prospective study of 48 eyes from 24 patients who underwent radical surgery for pituitary adenoma. Comprehensive ophthalmological assessment was performed and OCT (optical coherence tomography) parameters (RNFL - retinal nerve fiber layer, GCL - ganglion cell layer, BMO-MRW - Bruch&apos;s membrane opening-minimum rim width) and BVCA (best corrected visual acuity) using ETDRS (Early Treatment Diabetic Retinopathy Study) chart were evaluated before surgery and 3 months after surgery. Results:Over time, a decline in RNFL was observed in circular scans of 3.5 mm, 4.1 mm, and 4.7 mm (p = 0.001- 0.04), as well as in GCL (p = 0.001- 0.022) and BMO-MRW (p = 0.001- 0.033). The median improvement in vision was 4 letters (IQR 0- 6) (p &lt; 0.001). A positive correlation between RNFL and visual improvement was found only in the TS (temporo-superior) sector in the 4.7 mm circle (p = 0.018). A negative correlation was observed between the difference between preoperative and normative RNFL and GCL values and the postoperative BCVA (RNFL p = 0.005- 0.046, GCL p = 0.009- 0.022).Conclusion:Following radical surgery all three OCT parameters show a significant decline. While the reduction between preoperative and postoperative values does not influence the final visual outcome, preoperative atrophy of the RNFL and the GCL is negatively correlated with postoperative BCVA. The BMO-MRW may represent a novel marker of compressive neuropathy.

Název v anglickém jazyce

Structural and Functional Outcomes of Optic Pathway Compression in Pituitary Adenoma: A Prospective Pilot OCT Study

Popis výsledku anglicky

Purpose: To evaluate the anatomical and functional effects of optic chiasm compression caused by a pituitary adenoma both before and after surgery.Patients and Methods: Short-term prospective study of 48 eyes from 24 patients who underwent radical surgery for pituitary adenoma. Comprehensive ophthalmological assessment was performed and OCT (optical coherence tomography) parameters (RNFL - retinal nerve fiber layer, GCL - ganglion cell layer, BMO-MRW - Bruch&apos;s membrane opening-minimum rim width) and BVCA (best corrected visual acuity) using ETDRS (Early Treatment Diabetic Retinopathy Study) chart were evaluated before surgery and 3 months after surgery. Results:Over time, a decline in RNFL was observed in circular scans of 3.5 mm, 4.1 mm, and 4.7 mm (p = 0.001- 0.04), as well as in GCL (p = 0.001- 0.022) and BMO-MRW (p = 0.001- 0.033). The median improvement in vision was 4 letters (IQR 0- 6) (p &lt; 0.001). A positive correlation between RNFL and visual improvement was found only in the TS (temporo-superior) sector in the 4.7 mm circle (p = 0.018). A negative correlation was observed between the difference between preoperative and normative RNFL and GCL values and the postoperative BCVA (RNFL p = 0.005- 0.046, GCL p = 0.009- 0.022).Conclusion:Following radical surgery all three OCT parameters show a significant decline. While the reduction between preoperative and postoperative values does not influence the final visual outcome, preoperative atrophy of the RNFL and the GCL is negatively correlated with postoperative BCVA. The BMO-MRW may represent a novel marker of compressive neuropathy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30207 - Ophthalmology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Ophthalmology

ISSN

1177-5483

e-ISSN

1177-5483

Svazek periodika

19

Číslo periodika v rámci svazku

2025

Stát vydavatele periodika

NZ - Nový Zéland

Počet stran výsledku

13

Strana od-do

4433-4445

Kód UT WoS článku

001634810500001

EID výsledku v databázi Scopus

2-s2.0-105024192801