Elucidating the adaptation and temporal coordination of metabolic pathways using in-silico evolution

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67179843%3A_____%2F14%3A00442496" target="_blank" >RIV/67179843:_____/14:00442496 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.biosystems.2013.12.006" target="_blank" >http://dx.doi.org/10.1016/j.biosystems.2013.12.006</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biosystems.2013.12.006" target="_blank" >10.1016/j.biosystems.2013.12.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Elucidating the adaptation and temporal coordination of metabolic pathways using in-silico evolution

Popis výsledku v původním jazyce

Cellular metabolism, the interconversion of small molecules by chemical reactions, is a tightly coordinated process that requires integration of diverse environmental and intracellular cues. While for many organisms the topology of the network of metabolic reactions is increasingly known, the regulatory principles that shape the network's adaptation to diverse and changing environments remain largely elusive. To investigate the principles of metabolic adaptation and regulation in metabolic pathways, wepropose a computational approach based on in-silico evolution. Rather than analyzing existing regulatory schemes, we let a population of minimal, prototypical metabolic cells evolve rate constants and appropriate regulatory schemes that allow for optimalgrowth in static and fluctuating environments. Applying our approach to a small, but already sufficiently complex, minimal system reveals intricate transitions between metabolic modes. These results have implications for trade-offs in re

Název v anglickém jazyce

Elucidating the adaptation and temporal coordination of metabolic pathways using in-silico evolution

Popis výsledku anglicky

Cellular metabolism, the interconversion of small molecules by chemical reactions, is a tightly coordinated process that requires integration of diverse environmental and intracellular cues. While for many organisms the topology of the network of metabolic reactions is increasingly known, the regulatory principles that shape the network's adaptation to diverse and changing environments remain largely elusive. To investigate the principles of metabolic adaptation and regulation in metabolic pathways, wepropose a computational approach based on in-silico evolution. Rather than analyzing existing regulatory schemes, we let a population of minimal, prototypical metabolic cells evolve rate constants and appropriate regulatory schemes that allow for optimalgrowth in static and fluctuating environments. Applying our approach to a small, but already sufficiently complex, minimal system reveals intricate transitions between metabolic modes. These results have implications for trade-offs in re

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EI - Biotechnologie a bionika

OECD FORD obor

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Projekt

<a href="/cs/project/EE2.3.20.0256" target="_blank" >EE2.3.20.0256: Vytvoření výzkumného týmu a mezinárodního konzorcia pro počítačový model buňky sinice</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biosystems

ISSN

0303-2647

e-ISSN

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Svazek periodika

117

Číslo periodika v rámci svazku

mar

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

9

Strana od-do

68-76

Kód UT WoS článku

000333873000008

EID výsledku v databázi Scopus

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