Cardiac Autonomic Neuropathy May Play a Role in Pathogenesis of Atherosclerosis in Type 1 Diabetes Mellitus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F17%3A00479186" target="_blank" >RIV/67985807:_____/17:00479186 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21730/17:00320103 RIV/00216208:11130/17:10373472 RIV/00064203:_____/17:10373472

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.diabres.2017.10.002" target="_blank" >http://dx.doi.org/10.1016/j.diabres.2017.10.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.diabres.2017.10.002" target="_blank" >10.1016/j.diabres.2017.10.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cardiac Autonomic Neuropathy May Play a Role in Pathogenesis of Atherosclerosis in Type 1 Diabetes Mellitus

Popis výsledku v původním jazyce

Aims: Cardiac autonomic neuropathy(CAN) is a frequent and severe complication of type 1 diabetes mellitus(T1DM). CAN diagnosis is associated with increased cardiovascular morbidity and mortality, often due to progressive atherosclerosis. Carotid intima media thickness(CIMT) is a surrogate marker of the atherosclerosis. The aim of our study was to evaluate the relationship between CIMT and CAN in T1DM patients. Methods: Total of 49 T1DM patients and 45 healthy controls were examined for CAN presence and CIMT. CAN was diagnosed based on the results of Ewing test battery and spectral analysis of heart rate variability. CIMT was measured by two-dimensional ultrasound. Biochemical, anthropometric and anamnestic risk markers of atherosclerosis were evaluated. We used logistic types of generalized additive models(GAM) for statistical analysis. Results: CAN was detected in 22 out of 49 T1DM patients(45%). All 45 healthy controls had normal cardiovascular autonomic tests results. CIMT was significantly positively associated with T1DM diagnosis(p=0.0251), CAN diagnosis(p=0.007), age(p<0.0001), BMI(p=0.0435) and systolic blood pressure(p=0.0098). CAN effect on CIMT interacted with the effect of T1DM. The combination of both factors significantly increased CIMT more than the sum of the individual T1DM and CAN status. Conclusions: CAN is significantly associated with higher CIMT in T1DM patients. CAN may play a role in pathogenesis of atherosclerosis in type 1 diabetes mellitus.

Název v anglickém jazyce

Cardiac Autonomic Neuropathy May Play a Role in Pathogenesis of Atherosclerosis in Type 1 Diabetes Mellitus

Popis výsledku anglicky

Aims: Cardiac autonomic neuropathy(CAN) is a frequent and severe complication of type 1 diabetes mellitus(T1DM). CAN diagnosis is associated with increased cardiovascular morbidity and mortality, often due to progressive atherosclerosis. Carotid intima media thickness(CIMT) is a surrogate marker of the atherosclerosis. The aim of our study was to evaluate the relationship between CIMT and CAN in T1DM patients. Methods: Total of 49 T1DM patients and 45 healthy controls were examined for CAN presence and CIMT. CAN was diagnosed based on the results of Ewing test battery and spectral analysis of heart rate variability. CIMT was measured by two-dimensional ultrasound. Biochemical, anthropometric and anamnestic risk markers of atherosclerosis were evaluated. We used logistic types of generalized additive models(GAM) for statistical analysis. Results: CAN was detected in 22 out of 49 T1DM patients(45%). All 45 healthy controls had normal cardiovascular autonomic tests results. CIMT was significantly positively associated with T1DM diagnosis(p=0.0251), CAN diagnosis(p=0.007), age(p<0.0001), BMI(p=0.0435) and systolic blood pressure(p=0.0098). CAN effect on CIMT interacted with the effect of T1DM. The combination of both factors significantly increased CIMT more than the sum of the individual T1DM and CAN status. Conclusions: CAN is significantly associated with higher CIMT in T1DM patients. CAN may play a role in pathogenesis of atherosclerosis in type 1 diabetes mellitus.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10103 - Statistics and probability

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Diabetes Research and Clinical Practice

ISSN

0168-8227

e-ISSN

—

Svazek periodika

134

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

139-144

Kód UT WoS článku

000417318700016

EID výsledku v databázi Scopus

2-s2.0-85032588909