Long-term outcome of Simpson IV meningioma resection: Would it improve with adjuvant SRS?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F21%3A00552206" target="_blank" >RIV/67985807:_____/21:00552206 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61383082:_____/21:00001067 RIV/00216208:11110/21:10429200

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.clineuro.2021.106766" target="_blank" >http://dx.doi.org/10.1016/j.clineuro.2021.106766</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clineuro.2021.106766" target="_blank" >10.1016/j.clineuro.2021.106766</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Long-term outcome of Simpson IV meningioma resection: Would it improve with adjuvant SRS?

Popis výsledku v původním jazyce

Objective: Subtotal meningioma resection (STR) is often performed to minimize surgical morbidity. Nevertheless, only a few studies have reported on patient outcome after STR. We studied the long-term outcome of SIV (Simpson grade IV) resection and identified predictive factors of overall survival (OS), progression-free survival (PFS) and time to progression (TTP). Methods: A retrospective analysis was performed on 68 patients who underwent SIV resection of meningioma (grade I) from 2004 to 2010. Data were collected from clinical, surgical and pathology records and radiological imaging. Long-term outcomes were evaluated at least 10 years after surgery. Results: Permanent morbidity was 11.8%, 30-day mortality 2.9% and progression rate 50.0% for a median followup duration of 126.6 months. Median TTP was 86.2 months. Adjuvant SRS was the only significant factor associated with longer PFS (p = 0.0052) and TTP (p = 0.0079). Higher age (p = 0.0022), KPS (p = 0.0182), postoperative ECOG score (p = 0.0182) were reliable predictors of shortened OS and aSRS (p = 0.0445) was reliable predictor of longer OS. Conclusion: STR in intracranial meningioma is still viable and often the only treatment option available in high risk patients or high-risk tumors. Although surgical morbidity and mortality are high, the OS rate was 85.3% at 5 years and 79.4% at 10 years. Because of the considerable progression rate and rather a long term OS the adjuvant SRS should be considered following SIV resection.

Název v anglickém jazyce

Long-term outcome of Simpson IV meningioma resection: Would it improve with adjuvant SRS?

Popis výsledku anglicky

Objective: Subtotal meningioma resection (STR) is often performed to minimize surgical morbidity. Nevertheless, only a few studies have reported on patient outcome after STR. We studied the long-term outcome of SIV (Simpson grade IV) resection and identified predictive factors of overall survival (OS), progression-free survival (PFS) and time to progression (TTP). Methods: A retrospective analysis was performed on 68 patients who underwent SIV resection of meningioma (grade I) from 2004 to 2010. Data were collected from clinical, surgical and pathology records and radiological imaging. Long-term outcomes were evaluated at least 10 years after surgery. Results: Permanent morbidity was 11.8%, 30-day mortality 2.9% and progression rate 50.0% for a median followup duration of 126.6 months. Median TTP was 86.2 months. Adjuvant SRS was the only significant factor associated with longer PFS (p = 0.0052) and TTP (p = 0.0079). Higher age (p = 0.0022), KPS (p = 0.0182), postoperative ECOG score (p = 0.0182) were reliable predictors of shortened OS and aSRS (p = 0.0445) was reliable predictor of longer OS. Conclusion: STR in intracranial meningioma is still viable and often the only treatment option available in high risk patients or high-risk tumors. Although surgical morbidity and mortality are high, the OS rate was 85.3% at 5 years and 79.4% at 10 years. Because of the considerable progression rate and rather a long term OS the adjuvant SRS should be considered following SIV resection.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

<a href="/cs/project/NV19-04-00272" target="_blank" >NV19-04-00272: Vztah origa meningiomu k arachnoidálním membránám, rozsahu resekce a chirurgickým rizikům</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Neurology and Neurosurgery

ISSN

0303-8467

e-ISSN

1872-6968

Svazek periodika

207

Číslo periodika v rámci svazku

August 2021

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

106766

Kód UT WoS článku

000715564200007

EID výsledku v databázi Scopus

2-s2.0-85108313746