Python/NEURON code for simulating biophysically realistic thalamocortical dynamics during sleep
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F24%3A00586406" target="_blank" >RIV/67985807:_____/24:00586406 - isvavai.cz</a>
Výsledek na webu
<a href="https://doi.org/10.1016/j.simpa.2024.100667" target="_blank" >https://doi.org/10.1016/j.simpa.2024.100667</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.simpa.2024.100667" target="_blank" >10.1016/j.simpa.2024.100667</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Python/NEURON code for simulating biophysically realistic thalamocortical dynamics during sleep
Popis výsledku v původním jazyce
Understanding the function of sleep and its associated neural rhythms is an important goal in neuroscience. While many theoretical models of neural dynamics during sleep exist, few include the effects of neuromodulators on sleep oscillations and describe transitions between sleep and wake states or different sleep stages. Here, we started with a C++-based thalamocortical network model that describes characteristic thalamic and cortical oscillations specific to sleep. This model, which includes a biophysically realistic description of intrinsic and synaptic channels, allows for testing the effects of different neuromodulators, intrinsic cell properties, and synaptic connectivity on neural dynamics during sleep. We present a complete reimplementation of this previously-published sleep model in the standardized NEURON/Python framework, making it more accessible to the wider scientific community.
Název v anglickém jazyce
Python/NEURON code for simulating biophysically realistic thalamocortical dynamics during sleep
Popis výsledku anglicky
Understanding the function of sleep and its associated neural rhythms is an important goal in neuroscience. While many theoretical models of neural dynamics during sleep exist, few include the effects of neuromodulators on sleep oscillations and describe transitions between sleep and wake states or different sleep stages. Here, we started with a C++-based thalamocortical network model that describes characteristic thalamic and cortical oscillations specific to sleep. This model, which includes a biophysically realistic description of intrinsic and synaptic channels, allows for testing the effects of different neuromodulators, intrinsic cell properties, and synaptic connectivity on neural dynamics during sleep. We present a complete reimplementation of this previously-published sleep model in the standardized NEURON/Python framework, making it more accessible to the wider scientific community.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Návaznosti výsledku
Projekt
<a href="/cs/project/EH22_008%2F0004643" target="_blank" >EH22_008/0004643: Dynamika mozku</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2024
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Software Impacts
ISSN
2665-9638
e-ISSN
2665-9638
Svazek periodika
21
Číslo periodika v rámci svazku
September 2024
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
4
Strana od-do
100667
Kód UT WoS článku
001258888000001
EID výsledku v databázi Scopus
2-s2.0-85196149652