Resting EEG partial coherence demonstrates increased γ range central functional connectivity in amnestic mild cognitive impairment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F25%3A00641461" target="_blank" >RIV/67985807:_____/25:00641461 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.brainres.2025.149973" target="_blank" >https://doi.org/10.1016/j.brainres.2025.149973</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.brainres.2025.149973" target="_blank" >10.1016/j.brainres.2025.149973</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Resting EEG partial coherence demonstrates increased γ range central functional connectivity in amnestic mild cognitive impairment

Popis výsledku v původním jazyce

OBJECTIVE: Relatively little is known about EEG high gamma (gamma) range changes in Alzheimer's disease (AD). We investigated functional connectivity, focusing on the gamma range, in amnestic Mild Cognitive Impairment (MCI) using ordinary Coherence (COH) and Partial Coherence (PCOH), a metric which enhances signal-to-noise ratio at high frequencies. METHODS: MCI (N=21) and Cognitively Normal (CN, N=62) ALBION study participants had resting EEG with eyes closed (EC) and eyes open (EO) in 10/20 montage (19 active electrodes). COH and PCOH in 0.5-100 Hz for each subject were calculated for all 171 electrode pairs. RESULTS: In both gamma1 (30-50 Hz) and gamma2 (50-100 Hz) ranges, PCOH was significantly higher in MCI than in CN in several electrode pairs, especially centrally, in both eye conditions. Concerning local (average of each electrode) connectivity, MCI compared to CN showed significantly higher values in PCOH centrally. CONCLUSIONS: Resting EEG gamma range functional connectivity at central areas, as revealed by PCOH, is significantly higher in MCI than in CN. SIGNIFICANCE: Gamma range local and regional EEG functional connectivity differences may help construct useful and easily available biomarkers in neurodegeneration. Metrics such as PCOH, which factor out global connectivity components, may help reveal such differences.

Název v anglickém jazyce

Resting EEG partial coherence demonstrates increased γ range central functional connectivity in amnestic mild cognitive impairment

Popis výsledku anglicky

OBJECTIVE: Relatively little is known about EEG high gamma (gamma) range changes in Alzheimer's disease (AD). We investigated functional connectivity, focusing on the gamma range, in amnestic Mild Cognitive Impairment (MCI) using ordinary Coherence (COH) and Partial Coherence (PCOH), a metric which enhances signal-to-noise ratio at high frequencies. METHODS: MCI (N=21) and Cognitively Normal (CN, N=62) ALBION study participants had resting EEG with eyes closed (EC) and eyes open (EO) in 10/20 montage (19 active electrodes). COH and PCOH in 0.5-100 Hz for each subject were calculated for all 171 electrode pairs. RESULTS: In both gamma1 (30-50 Hz) and gamma2 (50-100 Hz) ranges, PCOH was significantly higher in MCI than in CN in several electrode pairs, especially centrally, in both eye conditions. Concerning local (average of each electrode) connectivity, MCI compared to CN showed significantly higher values in PCOH centrally. CONCLUSIONS: Resting EEG gamma range functional connectivity at central areas, as revealed by PCOH, is significantly higher in MCI than in CN. SIGNIFICANCE: Gamma range local and regional EEG functional connectivity differences may help construct useful and easily available biomarkers in neurodegeneration. Metrics such as PCOH, which factor out global connectivity components, may help reveal such differences.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Brain Research

ISSN

0006-8993

e-ISSN

1872-6240

Svazek periodika

1867

Číslo periodika v rámci svazku

November 2025

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

17

Strana od-do

149973

Kód UT WoS článku

001588444200001

EID výsledku v databázi Scopus

2-s2.0-105017631471