Different expression of renin-angiotensin system components in hearts of normotensive and hypertensive rats.
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F01%3A20010177" target="_blank" >RIV/67985823:_____/01:20010177 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Different expression of renin-angiotensin system components in hearts of normotensive and hypertensive rats.
Popis výsledku v původním jazyce
The objective of this study was to compare the gene expression of individual components of the renin-angiotensin system (RAS) in hearts of normotensive and hypertensive rats. Two genetically hypertensive rat strains - spontaneously hypertensive rats (SHR) and hereditary hypertriglyceridemic rats (HTG) - were compared with Wistar-Kyoto (WKY) and Lewis (LEW) normotensive controls. In addition, developmental changes in gene expression of individual components of cardiac RAS were studied in 20-day-old fetuses, 2-day-old newborns and 3-month-old HTG and LEW rats. Angiotensinogen gene expression did not differ either among adult normotensive and hypertensive strains, or during development. The renin gene expression was significantly increased in hypertensiveheart when compared to normotensive one. There was also an age-dependent increase of ACE gene expression in both HTG and LEW rats, which was delayed in HTG hearts. Results suggest that overexpression of the cardiac renin gene in hyperten
Název v anglickém jazyce
Different expression of renin-angiotensin system components in hearts of normotensive and hypertensive rats.
Popis výsledku anglicky
The objective of this study was to compare the gene expression of individual components of the renin-angiotensin system (RAS) in hearts of normotensive and hypertensive rats. Two genetically hypertensive rat strains - spontaneously hypertensive rats (SHR) and hereditary hypertriglyceridemic rats (HTG) - were compared with Wistar-Kyoto (WKY) and Lewis (LEW) normotensive controls. In addition, developmental changes in gene expression of individual components of cardiac RAS were studied in 20-day-old fetuses, 2-day-old newborns and 3-month-old HTG and LEW rats. Angiotensinogen gene expression did not differ either among adult normotensive and hypertensive strains, or during development. The renin gene expression was significantly increased in hypertensiveheart when compared to normotensive one. There was also an age-dependent increase of ACE gene expression in both HTG and LEW rats, which was delayed in HTG hearts. Results suggest that overexpression of the cardiac renin gene in hyperten
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FA - Kardiovaskulární nemoci včetně kardiochirurgie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/IAA7011805" target="_blank" >IAA7011805: Volné kyslíkové radikály a oxid dusnatý v patogenezi věkově závislé experimentální hypertenze: oslabení vasodilatačních mech. zvýš. oxidačním stresem</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2001
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Physiological Research
ISSN
0862-8408
e-ISSN
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Svazek periodika
50
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
8
Strana od-do
35-42
Kód UT WoS článku
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EID výsledku v databázi Scopus
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