Early changes in extrafusal and intrafusal muscle fibers following heterochronous isotransplantation.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F01%3A20010274" target="_blank" >RIV/67985823:_____/01:20010274 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Early changes in extrafusal and intrafusal muscle fibers following heterochronous isotransplantation.

Popis výsledku v původním jazyce

The ultrastructure of regenerating intrafusal and extrafusal fibres was studied 18 hours to 30 days after heterochronous isotransplantation, when bupivacaine-treated EDL or soleus muscles from early postnatal rats were intramuscularly grafted into EDL muscles of adult inbred recipients. Similarly as in other models of mammalian muscle regeneration, surviving satellite cells gave rise to presumptive myoblasts multiplying within the preserved basal lamina tubes at day 4 after grafting, myoblasts fused toform myotubes with central myonuclei by day 6 after grafting. Extrafusal myotubes differentiated into thin muscle fibres by day 8, which progressively increased in diameter and their nuclei became localized subsarcolemmally from day 13 onwards. The basallaminae of some intrafusal fibres already contained one or more nascent myotubes by day 4 after grafting. Regenerated intrafusal fibres lacked the typical nuclear accumulations and their number varied from 1 to 8 fibres per spindle; addi

Název v anglickém jazyce

Early changes in extrafusal and intrafusal muscle fibers following heterochronous isotransplantation.

Popis výsledku anglicky

The ultrastructure of regenerating intrafusal and extrafusal fibres was studied 18 hours to 30 days after heterochronous isotransplantation, when bupivacaine-treated EDL or soleus muscles from early postnatal rats were intramuscularly grafted into EDL muscles of adult inbred recipients. Similarly as in other models of mammalian muscle regeneration, surviving satellite cells gave rise to presumptive myoblasts multiplying within the preserved basal lamina tubes at day 4 after grafting, myoblasts fused toform myotubes with central myonuclei by day 6 after grafting. Extrafusal myotubes differentiated into thin muscle fibres by day 8, which progressively increased in diameter and their nuclei became localized subsarcolemmally from day 13 onwards. The basallaminae of some intrafusal fibres already contained one or more nascent myotubes by day 4 after grafting. Regenerated intrafusal fibres lacked the typical nuclear accumulations and their number varied from 1 to 8 fibres per spindle; addi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/GA304%2F00%2F1653" target="_blank" >GA304/00/1653: Regulace exprese fenotypu svalových vláken hormony štítné žlázy</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2001

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Neuropathologica

ISSN

0001-6322

e-ISSN

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Svazek periodika

102

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

473-484

Kód UT WoS článku

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EID výsledku v databázi Scopus

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