Leksell gamma knife lesioning of the rat hippocampus: the relationship between radiation dose and functional and structural damage.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F02%3A20020111" target="_blank" >RIV/67985823:_____/02:20020111 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/02:00000064 RIV/00216208:11130/02:00000059

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Leksell gamma knife lesioning of the rat hippocampus: the relationship between radiation dose and functional and structural damage.

Popis výsledku v původním jazyce

The aim of the study was to determine at what dosage and after how long impairment of hippocampal function occurs, following radiosurgery of the rat hippocampus using the Leksell gamma knife, and to study the associated structural changes. The Long-Evansrats were irradiated with the doses of 25, 50, 75, 100 and 150 Gy to a maximum, using 4 isocenters of 4mm collimator to cover the hippocampus bilaterally. The impairment of hippocampal function, which is associated with a loss of memory, was measured bytesting the impairment of the rats' orientation in a Morris water maze. Changes in the irradiated tissue of the rats were measured by means of MR imaging using a Bruker 4.7/20 experimental spectrometer. The data obtained by these measurements were compared with histological changes. A significantly higher frequency of edema, necrosis and behavioral changes was observed for doses higher than 50 Gy. No edema, necrosis and behavioral changes were observed for doses of 25 Gy. The study show

Název v anglickém jazyce

Leksell gamma knife lesioning of the rat hippocampus: the relationship between radiation dose and functional and structural damage.

Popis výsledku anglicky

The aim of the study was to determine at what dosage and after how long impairment of hippocampal function occurs, following radiosurgery of the rat hippocampus using the Leksell gamma knife, and to study the associated structural changes. The Long-Evansrats were irradiated with the doses of 25, 50, 75, 100 and 150 Gy to a maximum, using 4 isocenters of 4mm collimator to cover the hippocampus bilaterally. The impairment of hippocampal function, which is associated with a loss of memory, was measured bytesting the impairment of the rats' orientation in a Morris water maze. Changes in the irradiated tissue of the rats were measured by means of MR imaging using a Bruker 4.7/20 experimental spectrometer. The data obtained by these measurements were compared with histological changes. A significantly higher frequency of edema, necrosis and behavioral changes was observed for doses higher than 50 Gy. No edema, necrosis and behavioral changes were observed for doses of 25 Gy. The study show

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BG - Jaderná, atomová a molekulová fyzika, urychlovače

OECD FORD obor

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Projekt

<a href="/cs/project/NF5161" target="_blank" >NF5161: Radiochirurgická léze hipokampu u laboratorního potkana Leksellovým gama nožem: vztah mezi radiační dávkou, funkčním a strukturálním poškozením hipokampu.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2002

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neurosurgery

ISSN

0022-3085

e-ISSN

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Svazek periodika

97

Číslo periodika v rámci svazku

Suppl. 5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

666-673

Kód UT WoS článku

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EID výsledku v databázi Scopus

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