Experimental photodynamic therapy with MESO-tetrakisphenylporphyrin (TPP) in liposomes leads to disintegration of human amelanotic melanoma implanted to nude mice.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F03%3A20030005" target="_blank" >RIV/67985823:_____/03:20030005 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Experimental photodynamic therapy with MESO-tetrakisphenylporphyrin (TPP) in liposomes leads to disintegration of human amelanotic melanoma implanted to nude mice.

Popis výsledku v původním jazyce

Liposomal meso-tetrakis-phenylporphyrin (TPP) was tested for photodynamic therapy (PDT) of human amelanotic melanomas implanted to nude mice. After intratumoural TPP application (15 mg.kg-1) followed by PDT lamp irradiation (600 - 700 nm, 635 nm peak) tumours retained their original volume up to the 23rd day post PDT, whereas volumes increased six times in controls. PDT with intravenously (iv.) administered liposomal (3.2 mg.kg-1) TPP mostly disintegrated tumours to zero volumes. Melanoma remissions were accompanied by tumour surface necroses and were documented by the appearance of nontumourous cells with non-pycnotic nuclei. Spatial arrangement of capillaries in remising tumour was the same as in healthy surrounding tissue. Lower TPP doses (1, 0.3, and 0.1 mg.kg-1) were more or equally efficient than hydrophilic TPPS4 (3.2 mg.kg-1, i.e. sulfonated TPP), iv. administered also in liposomes. Liposomal TPPS4 only delayed the onset of subsequent tumour growth. Commercial Photosan 3 disint

Název v anglickém jazyce

Experimental photodynamic therapy with MESO-tetrakisphenylporphyrin (TPP) in liposomes leads to disintegration of human amelanotic melanoma implanted to nude mice.

Popis výsledku anglicky

Liposomal meso-tetrakis-phenylporphyrin (TPP) was tested for photodynamic therapy (PDT) of human amelanotic melanomas implanted to nude mice. After intratumoural TPP application (15 mg.kg-1) followed by PDT lamp irradiation (600 - 700 nm, 635 nm peak) tumours retained their original volume up to the 23rd day post PDT, whereas volumes increased six times in controls. PDT with intravenously (iv.) administered liposomal (3.2 mg.kg-1) TPP mostly disintegrated tumours to zero volumes. Melanoma remissions were accompanied by tumour surface necroses and were documented by the appearance of nontumourous cells with non-pycnotic nuclei. Spatial arrangement of capillaries in remising tumour was the same as in healthy surrounding tissue. Lower TPP doses (1, 0.3, and 0.1 mg.kg-1) were more or equally efficient than hydrophilic TPPS4 (3.2 mg.kg-1, i.e. sulfonated TPP), iv. administered also in liposomes. Liposomal TPPS4 only delayed the onset of subsequent tumour growth. Commercial Photosan 3 disint

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Cancer

ISSN

0020-7136

e-ISSN

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Svazek periodika

103

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

693-702

Kód UT WoS článku

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EID výsledku v databázi Scopus

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