Vliv chemické struktury alifatických polyesterů na adhesi a růst osteoblastických buněk MG 63

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F04%3A00104207" target="_blank" >RIV/67985823:_____/04:00104207 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

The influence of chemical structure of aliphatic polyesters on adhesion and growth of osteoblast-like MG63 cells

Popis výsledku v původním jazyce

Degradable copolymers of glycolide and L-lactide (PGLA), glycolide and epsilon-caprolactone (PGCap) and terpolymer of glycolide, L-lactide and epsilon-caprolactone (PGLCap) were synthesized by ring opening polymerization and their interaction with osteoblast-like MG63 cells was tested in vitro. the cell behaviour on PGLA and PGLCap was very similar as on control tissue culture polystyrene (TCPS). On PGCap, however, the number of initially adhering cells was significantly lower (by 84% than on TCPS) andcell spreading area smaller (by 50%). On day 7 after seeding, these cells also reached the lowest populaton density. We hypothesize that the lower cell adhesion and growth of MG63 cells on PGCap was caused by the highest hydrophobicity of this material among all studied samples.

Název v anglickém jazyce

The influence of chemical structure of aliphatic polyesters on adhesion and growth of osteoblast-like MG63 cells

Popis výsledku anglicky

Degradable copolymers of glycolide and L-lactide (PGLA), glycolide and epsilon-caprolactone (PGCap) and terpolymer of glycolide, L-lactide and epsilon-caprolactone (PGLCap) were synthesized by ring opening polymerization and their interaction with osteoblast-like MG63 cells was tested in vitro. the cell behaviour on PGLA and PGLCap was very similar as on control tissue culture polystyrene (TCPS). On PGCap, however, the number of initially adhering cells was significantly lower (by 84% than on TCPS) andcell spreading area smaller (by 50%). On day 7 after seeding, these cells also reached the lowest populaton density. We hypothesize that the lower cell adhesion and growth of MG63 cells on PGCap was caused by the highest hydrophobicity of this material among all studied samples.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EI - Biotechnologie a bionika

OECD FORD obor

—

Projekt

<a href="/cs/project/OC%20527.130" target="_blank" >OC 527.130: Biokompatibilita a antimikrobiální vlastnosti tvrdých polymerních kompozitních vrstev na biofunkčních podložkách in vitro</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Engineering of Biomaterials

ISSN

1429-7248

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

37

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

4

Strana od-do

14-17

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—