Adhese kostních a cévních buněk na uhlíkové kompozity pokryté vrstvou fullerenů

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F05%3A00025186" target="_blank" >RIV/67985823:_____/05:00025186 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Adhesion of bone and vascular cells on carbon fibre-reinforced carbon composites coated with a fullerene layer

Popis výsledku v původním jazyce

Carbon fibre-reinforced carbon composites (CFRC), i.e. materials promising for hard tissue surgery, were coated by a fullerene layer in order to strengthen the material surface and create its nanostructure pattern which is known to be attractive for colonization with bone cells. Both human osteoblast-like MG 63 cells and rat vascular smooth muscle cells in 1- and 2-day-old cultures adhered to these surfaces in lower numbers in comparison with the control uncoated material and tissue culture polystyrene.On the other hand, the spreading of MG 63 cells was comparable to that observed on the control surfaces, and these cells also assembled dot-like vinculin-containing focal adhesion plaques and relatively rich fine filamentous beta-actin cytoskeleton. Wesuppose that the cell adhesion may be enhanced by derivatization of fullerenes with specific chemical functional groups or peptidic ligands for cell adhesion receptors

Název v anglickém jazyce

Adhesion of bone and vascular cells on carbon fibre-reinforced carbon composites coated with a fullerene layer

Popis výsledku anglicky

Carbon fibre-reinforced carbon composites (CFRC), i.e. materials promising for hard tissue surgery, were coated by a fullerene layer in order to strengthen the material surface and create its nanostructure pattern which is known to be attractive for colonization with bone cells. Both human osteoblast-like MG 63 cells and rat vascular smooth muscle cells in 1- and 2-day-old cultures adhered to these surfaces in lower numbers in comparison with the control uncoated material and tissue culture polystyrene.On the other hand, the spreading of MG 63 cells was comparable to that observed on the control surfaces, and these cells also assembled dot-like vinculin-containing focal adhesion plaques and relatively rich fine filamentous beta-actin cytoskeleton. Wesuppose that the cell adhesion may be enhanced by derivatization of fullerenes with specific chemical functional groups or peptidic ligands for cell adhesion receptors

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EI - Biotechnologie a bionika

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Engineering of Biomaterials

ISSN

1429-7248

e-ISSN

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Svazek periodika

8

Číslo periodika v rámci svazku

47-53

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

4

Strana od-do

3-6

Kód UT WoS článku

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EID výsledku v databázi Scopus

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