Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F11%3A00366420" target="_blank" >RIV/67985823:_____/11:00366420 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.neuroscience.2011.09.028" target="_blank" >http://dx.doi.org/10.1016/j.neuroscience.2011.09.028</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neuroscience.2011.09.028" target="_blank" >10.1016/j.neuroscience.2011.09.028</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light

Popis výsledku v původním jazyce

The aim of the study was to elucidate whether feeding regime may affect the molecular mechanisms generating rhythmicity in the suprachiasmatic nucleus (SCN) under conditions in which the rhythmicity is disturbed, as occurs under constant light. Due to exposure to constant light, the rats fed ad libitum became arrhythmic, while those exposed to restricted feeding were active mostly during the time of food availability. Restricted feeding induced significant circadian rhythms in Rev-erb? and Bmal1 gene expression in the SCN. These finding demonstrate that, under specific conditions, when the rhythmicity of the SCN is disturbed and other temporal entraining cues are lacking, the SCN molecular clockwork may likely sense temporal signals from changes in metabolic state delivered by normocaloric food

Název v anglickém jazyce

Restricted feeding regime affects clock gene expression profiles in the suprachiasmatic nucleus of rats exposed to constant light

Popis výsledku anglicky

The aim of the study was to elucidate whether feeding regime may affect the molecular mechanisms generating rhythmicity in the suprachiasmatic nucleus (SCN) under conditions in which the rhythmicity is disturbed, as occurs under constant light. Due to exposure to constant light, the rats fed ad libitum became arrhythmic, while those exposed to restricted feeding were active mostly during the time of food availability. Restricted feeding induced significant circadian rhythms in Rev-erb? and Bmal1 gene expression in the SCN. These finding demonstrate that, under specific conditions, when the rhythmicity of the SCN is disturbed and other temporal entraining cues are lacking, the SCN molecular clockwork may likely sense temporal signals from changes in metabolic state delivered by normocaloric food

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroscience

ISSN

0306-4522

e-ISSN

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Svazek periodika

197

Číslo periodika v rámci svazku

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Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

65-71

Kód UT WoS článku

000297140700007

EID výsledku v databázi Scopus

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