TRPV1 antagonist attenuates postoperative hypersensitivity by central and peripheral mechanisms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00435671" target="_blank" >RIV/67985823:_____/14:00435671 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1186/1744-8069-10-67" target="_blank" >http://dx.doi.org/10.1186/1744-8069-10-67</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1744-8069-10-67" target="_blank" >10.1186/1744-8069-10-67</a>

Jazyk výsledku

angličtina

Název v původním jazyce

TRPV1 antagonist attenuates postoperative hypersensitivity by central and peripheral mechanisms

Popis výsledku v původním jazyce

Acute postoperative pain is one of the frequent reasons for pain treatment. However, the exact mechanisms of its development are still not completely clear. Transient receptor potential vanilloid 1 (TRPV1) receptors are involved in nociceptive signalingin various hypersensitive states. Here we have investigated the contribution of TRPV1 receptors expressed on cutaneous peripheral nociceptive fibers and in the spinal cord on the development and maintenance of hypersensitivity to thermal and mechanical stimuli following surgical incision. A rat plantar incision model was used to test paw withdrawal responses to thermal and mechanical stimuli. The effect of the TRPV1 receptor antagonist SB366791 was investigated 1) by intrathecal injection 15 min beforeincision and 2) intradermal injection before (30 min) and immediately after the surgery. Vehicle-injected rats and na?ve animals treated identically were used as controls

Název v anglickém jazyce

TRPV1 antagonist attenuates postoperative hypersensitivity by central and peripheral mechanisms

Popis výsledku anglicky

Acute postoperative pain is one of the frequent reasons for pain treatment. However, the exact mechanisms of its development are still not completely clear. Transient receptor potential vanilloid 1 (TRPV1) receptors are involved in nociceptive signalingin various hypersensitive states. Here we have investigated the contribution of TRPV1 receptors expressed on cutaneous peripheral nociceptive fibers and in the spinal cord on the development and maintenance of hypersensitivity to thermal and mechanical stimuli following surgical incision. A rat plantar incision model was used to test paw withdrawal responses to thermal and mechanical stimuli. The effect of the TRPV1 receptor antagonist SB366791 was investigated 1) by intrathecal injection 15 min beforeincision and 2) intradermal injection before (30 min) and immediately after the surgery. Vehicle-injected rats and na?ve animals treated identically were used as controls

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular Pain

ISSN

1744-8069

e-ISSN

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Svazek periodika

10

Číslo periodika v rámci svazku

2014

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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