Direct comparison of health effects by dietary polyphenols at equimolar doses in wildtype moderate high-fat fed C57BL/6JOlaHsd mice

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00435721" target="_blank" >RIV/67985823:_____/14:00435721 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.foodres.2014.03.050" target="_blank" >http://dx.doi.org/10.1016/j.foodres.2014.03.050</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.foodres.2014.03.050" target="_blank" >10.1016/j.foodres.2014.03.050</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Direct comparison of health effects by dietary polyphenols at equimolar doses in wildtype moderate high-fat fed C57BL/6JOlaHsd mice

Popis výsledku v původním jazyce

We performed a systematic phenotypic evaluation of the effects of selected polyphenols (Epigallocatechin-gallate, quercetin, and resveratrol) in wildtype C57BL/6JOlaHsd mice fed high fat diet for 12 weeks. Results showed that these polyphenols were present in circulation, but did not induce beneficial health effects as analyzed by oral glucose tolerance testing or serum adipokines and CVD-markers such as vascular adhesion molecules. Remarkably, transcriptomics of white adipose tissue showed overlappingsets of significantly differential transcript levels between these polyphenols; AMPK and Notch signaling were affected by these polyphenols. However, mitochondrial processes and mitochondrial density in this tissue did not differ between the polyphenols,which suggested that there was no direct effect on adipose tissue

Název v anglickém jazyce

Direct comparison of health effects by dietary polyphenols at equimolar doses in wildtype moderate high-fat fed C57BL/6JOlaHsd mice

Popis výsledku anglicky

We performed a systematic phenotypic evaluation of the effects of selected polyphenols (Epigallocatechin-gallate, quercetin, and resveratrol) in wildtype C57BL/6JOlaHsd mice fed high fat diet for 12 weeks. Results showed that these polyphenols were present in circulation, but did not induce beneficial health effects as analyzed by oral glucose tolerance testing or serum adipokines and CVD-markers such as vascular adhesion molecules. Remarkably, transcriptomics of white adipose tissue showed overlappingsets of significantly differential transcript levels between these polyphenols; AMPK and Notch signaling were affected by these polyphenols. However, mitochondrial processes and mitochondrial density in this tissue did not differ between the polyphenols,which suggested that there was no direct effect on adipose tissue

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Food Research International

ISSN

0963-9969

e-ISSN

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Svazek periodika

65

Číslo periodika v rámci svazku

part A

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

95-102

Kód UT WoS článku

000347756000013

EID výsledku v databázi Scopus

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