A1 not A2A adenosine receptors play a role in cortical epileptic afterdischarges in immature rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F14%3A00439460" target="_blank" >RIV/67985823:_____/14:00439460 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00702-014-1234-y" target="_blank" >http://dx.doi.org/10.1007/s00702-014-1234-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-014-1234-y" target="_blank" >10.1007/s00702-014-1234-y</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A1 not A2A adenosine receptors play a role in cortical epileptic afterdischarges in immature rats

Popis výsledku v původním jazyce

Endo- as well as exogenous adenosine exhibits anticonvulsant action. Participation of individual types of adenosine receptors was studied in present experiments in immature rats. Cortical epileptic afterdischarges were used as a model in rat pups 12, 18and 25 days old. CCPA, an agonist of A1 adenosine receptors, decreased markedly duration of afterdischarges whereas DPCPX, an antagonist of A1 receptors, exhibited strong proconvulsant action. Action of either drug was best expressed in 12-day-old rats and it decreased with age. Drugs influencing A2A adenosine receptors (agonist CGS21680 and antagonist ZM241385) did not exhibit systematic effects in our model. Motor phenomena accompanying cortical stimulation or epileptic afterdischarge were never influenced by any of the four drugs studied. A1 adenosine receptors are important in the model of cortical seizures, especially in the youngest group studied

Název v anglickém jazyce

A1 not A2A adenosine receptors play a role in cortical epileptic afterdischarges in immature rats

Popis výsledku anglicky

Endo- as well as exogenous adenosine exhibits anticonvulsant action. Participation of individual types of adenosine receptors was studied in present experiments in immature rats. Cortical epileptic afterdischarges were used as a model in rat pups 12, 18and 25 days old. CCPA, an agonist of A1 adenosine receptors, decreased markedly duration of afterdischarges whereas DPCPX, an antagonist of A1 receptors, exhibited strong proconvulsant action. Action of either drug was best expressed in 12-day-old rats and it decreased with age. Drugs influencing A2A adenosine receptors (agonist CGS21680 and antagonist ZM241385) did not exhibit systematic effects in our model. Motor phenomena accompanying cortical stimulation or epileptic afterdischarge were never influenced by any of the four drugs studied. A1 adenosine receptors are important in the model of cortical seizures, especially in the youngest group studied

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/LH11015" target="_blank" >LH11015: Studium bezprostředních změn po epileptickém záchvatu vyvolaném v různých stadiích postnatálního vývoje</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Neural Transmission

ISSN

0300-9564

e-ISSN

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Svazek periodika

121

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

8

Strana od-do

1329-1336

Kód UT WoS článku

000344353700002

EID výsledku v databázi Scopus

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