Cell type-specific modulation of lipid mediator's formation in murine adipose tissue by omega-3 fatty acids

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00458422" target="_blank" >RIV/67985823:_____/16:00458422 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/16:10321667

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.bbrc.2015.12.055" target="_blank" >http://dx.doi.org/10.1016/j.bbrc.2015.12.055</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbrc.2015.12.055" target="_blank" >10.1016/j.bbrc.2015.12.055</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cell type-specific modulation of lipid mediator's formation in murine adipose tissue by omega-3 fatty acids

Popis výsledku v původním jazyce

The fractionation and metabolipidomic analysis were used to identify cells producing lipid mediators in epididymal WAT of mice fed for 5 weeks obesogenic high-fat diet (lipid content 35% wt/wt), which was supplemented or not by omega-3 PUFA (4.3 mg eicosapentaenoic acid and 14.7 mg docosahexaenoic acid per g of diet). Our results demonstrate selective increase in levels of anti-inflammatory lipid mediators in WAT in response to omega-3, reflecting either their association with adipocytes (endocannabinoid-related N-docosahexaenoylethanolamine) or with stromal vascular cells (pro-resolving lipid mediator protectin D1). These results further document specific roles of various cell types in WAT in control of WAT inflammation and metabolism and they suggest that also other cells but ATMs are engaged in production of proresolving lipid mediators in response to omega-3 PUFA.

Název v anglickém jazyce

Cell type-specific modulation of lipid mediator's formation in murine adipose tissue by omega-3 fatty acids

Popis výsledku anglicky

The fractionation and metabolipidomic analysis were used to identify cells producing lipid mediators in epididymal WAT of mice fed for 5 weeks obesogenic high-fat diet (lipid content 35% wt/wt), which was supplemented or not by omega-3 PUFA (4.3 mg eicosapentaenoic acid and 14.7 mg docosahexaenoic acid per g of diet). Our results demonstrate selective increase in levels of anti-inflammatory lipid mediators in WAT in response to omega-3, reflecting either their association with adipocytes (endocannabinoid-related N-docosahexaenoylethanolamine) or with stromal vascular cells (pro-resolving lipid mediator protectin D1). These results further document specific roles of various cell types in WAT in control of WAT inflammation and metabolism and they suggest that also other cells but ATMs are engaged in production of proresolving lipid mediators in response to omega-3 PUFA.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biochemical and Biophysical Research Communications

ISSN

0006-291X

e-ISSN

—

Svazek periodika

469

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

731-736

Kód UT WoS článku

000369352800062

EID výsledku v databázi Scopus

2-s2.0-84953635674