Utilization of Superfused Cerebral Slices in Probing Muscarinic Receptor Autoregulation of Acetylcholine Release

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F16%3A00458556" target="_blank" >RIV/67985823:_____/16:00458556 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-1-4939-2858-3_12" target="_blank" >http://dx.doi.org/10.1007/978-1-4939-2858-3_12</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-1-4939-2858-3_12" target="_blank" >10.1007/978-1-4939-2858-3_12</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Utilization of Superfused Cerebral Slices in Probing Muscarinic Receptor Autoregulation of Acetylcholine Release

Popis výsledku v původním jazyce

Signal transmission from cholinergic nerves is mediated by two receptor families: ionotropic nicotinic and metabotropic (G-protein coupled) muscarinic receptors. The muscarinic receptor family comprises five receptor subtypes (M1 through M5), each encoded by its own gene. Individual subtypes play important specific roles in many physiological processes, ranging from vegetative to cognitive functions and memory. Cloning of individual muscarinic receptor subtypes has enabled targeted studies of ligand binding and activation characteristics of the recombinant protein and a rapid increase in the development of receptor selective drugs for various potential therapeutic uses. Results of testing new drugs obtained on recombinant proteins need to be verified using systems that better mimic a physiological environment. Here we provide a brief outline and examples of the utilization of superfused brain slices for probing drug effects on muscarinic autoreceptor-mediated regulation of acetylcholine release.

Název v anglickém jazyce

Utilization of Superfused Cerebral Slices in Probing Muscarinic Receptor Autoregulation of Acetylcholine Release

Popis výsledku anglicky

Signal transmission from cholinergic nerves is mediated by two receptor families: ionotropic nicotinic and metabotropic (G-protein coupled) muscarinic receptors. The muscarinic receptor family comprises five receptor subtypes (M1 through M5), each encoded by its own gene. Individual subtypes play important specific roles in many physiological processes, ranging from vegetative to cognitive functions and memory. Cloning of individual muscarinic receptor subtypes has enabled targeted studies of ligand binding and activation characteristics of the recombinant protein and a rapid increase in the development of receptor selective drugs for various potential therapeutic uses. Results of testing new drugs obtained on recombinant proteins need to be verified using systems that better mimic a physiological environment. Here we provide a brief outline and examples of the utilization of superfused brain slices for probing drug effects on muscarinic autoreceptor-mediated regulation of acetylcholine release.

Druh

C - Kapitola v odborné knize

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Muscarinic Receptor: From Structure to Animal Models

ISBN

978-1-4939-2857-6

Počet stran výsledku

13

Strana od-do

221-233

Počet stran knihy

287

Název nakladatele

Springer

Místo vydání

New York

Kód UT WoS kapitoly

—